INT166599

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Context Info
Confidence 0.47
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.72
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ntf3) cytoplasmic membrane-bounded vesicle (Ntf3)
Anatomy Link Frequency
precursor cells 2
Ntf3 (Mus musculus)
Pain Link Frequency Relevance Heat
neurotrophin 3 16 100.00 Very High Very High Very High
Nerve growth factor 5 94.36 High High
long-term potentiation 2 87.12 High High
Central nervous system 16 72.00 Quite High
Pain 1 62.32 Quite High
cerebral cortex 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 96 99.62 Very High Very High Very High
Neuropathy 4 98.98 Very High Very High Very High
Hereditary Sensory And Autonomic Neuropathies 2 98.58 Very High Very High Very High
Apoptosis 2 93.92 High High
Cytomegalovirus Infection 112 92.56 High High
Viral Infection 26 79.20 Quite High
Intellectual Impairment 6 69.76 Quite High
Pain 1 62.32 Quite High
Neurodegenerative Disease 12 50.00 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 20.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduced DCX expression was also associated with decreased neurotrophin expression.
Negative_regulation (decreased) of Gene_expression (expression) of neurotrophin
1) Confidence 0.47 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 1.09 Pain Relevance 0
Further validation of proliferation arrest in neuronal precursor cells and reduced DCX expression with progressive infection was obtained from decreased expression of neurotrophins, such as BDNF and NT3.
Negative_regulation (decreased) of Gene_expression (expression) of NT3 in precursor cells associated with neurotrophin 3 and infection
2) Confidence 0.41 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 1.10 Pain Relevance 0.17
Second, we envision that CIPA/HSAN IV polyneuropathies might fall into two different subgroups: one with diminished NT3/TrkAII signaling, in which axons actually do not reach their targets, and a second group with sufficient NT3/TrkAII signaling but diminished NGF/TrkAII signaling, in which axons do reach their targets, yet degenerate after successful target engagement.
Negative_regulation (diminished) of Gene_expression (/) of NT3 associated with neuropathy, nerve growth factor and hereditary sensory and autonomic neuropathies
3) Confidence 0.17 Published 2010 Journal Exp. Neurol. Section Abstract Doc Link 20188729 Disease Relevance 0.53 Pain Relevance 0.26

General Comments

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