INT166628

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Context Info
Confidence 0.67
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.03
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Becn1) cytoplasmic membrane-bounded vesicle (Becn1) cell cycle (Becn1)
molecular_function (Becn1) protein complex (Becn1) cellular_component (Becn1)
Anatomy Link Frequency
hearts 2
Becn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 10 99.98 Very High Very High Very High
ischemia 5 99.52 Very High Very High Very High
Hippocampus 2 94.16 High High
addiction 1 87.32 High High
agonist 1 78.16 Quite High
adenocard 1 77.28 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 4 99.52 Very High Very High Very High
Neuroblastoma 2 92.52 High High
Injury 2 88.04 High High
Drug Dependence 1 87.32 High High
Targeted Disruption 1 83.60 Quite High
Coronary Artery Disease 1 80.68 Quite High
Myocardial Reperfusion Injury 1 75.00 Quite High
Death 1 74.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ischemia or reperfusion did not enhance Beclin 1 expression, suggesting that Beclin 1 may not be critical for the formation of autophagy in isolated rat hearts. 3-methyladenine (3-MA), a classical inhibitor of autophagy, suppressed reperfusion-induced autophagy and reduced the infarct size when introduced at reperfusion.
Neg (not) Positive_regulation (enhance) of Gene_expression (expression) of Beclin 1 in hearts associated with ischemia
1) Confidence 0.67 Published 2010 Journal Front Biosci (Elite Ed) Section Abstract Doc Link 20515786 Disease Relevance 0.52 Pain Relevance 0.38
Morphine increases Beclin 1 expression and reduces the interaction between Beclin 1 and Bcl-2, thus releasing Beclin 1 for its pro-autophagic activity.
Positive_regulation (increases) of Gene_expression (expression) of Beclin 1 associated with morphine
2) Confidence 0.65 Published 2010 Journal Autophagy Section Abstract Doc Link 20190558 Disease Relevance 0.50 Pain Relevance 0.85

General Comments

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