INT166644

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.14
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.04
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 2
lung 1
Cd8a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 29 99.64 Very High Very High Very High
ischemia 72 98.60 Very High Very High Very High
fibrosis 8 97.20 Very High Very High Very High
cytokine 31 93.28 High High
Inflammatory response 5 90.64 High High
Inflammatory marker 1 88.48 High High
agonist 18 76.96 Quite High
metalloproteinase 31 58.88 Quite High
depression 3 51.28 Quite High
Thoracotomy 4 48.56 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 34 99.64 Very High Very High Very High
Transient Ischemic Attack 16 99.36 Very High Very High Very High
Reperfusion Injury 194 99.20 Very High Very High Very High
Targeted Disruption 2 98.98 Very High Very High Very High
Cancer 49 98.36 Very High Very High Very High
Pulmonary Fibrosis 2 97.40 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 79 88.68 High High
Shock 2 84.24 Quite High
Malignant Neoplastic Disease 6 77.84 Quite High
Disease 16 74.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our experiment, the number of CD8+ CTLs per unit volume was increased 23 hours after transient cerebral ischemia, but agmatine treatment cannot significantly affect the number of CD8+ CTLs per unit volume.
Positive_regulation (increased) of CD8 associated with transient ischemic attack and ischemia
1) Confidence 0.14 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998779 Disease Relevance 0.68 Pain Relevance 0.27
This relationship appeared to result mainly from a decrease in CD4+ T cells and an increase in CD8+ T cells, especially in group B, as the tumor progressed.
Positive_regulation (increase) of CD8 in T cells associated with cancer
2) Confidence 0.13 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1821034 Disease Relevance 0.83 Pain Relevance 0.04
Increased CD4+ and CD8+ cell counts and an elevation of CD8+:CD4+ ratio are also observed.
Positive_regulation (elevation) of CD8
3) Confidence 0.12 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629967 Disease Relevance 0.56 Pain Relevance 0.13
New results from an HLA-B27 transgenic rat model now demonstrate quite convincingly that CD8(+) T cells are not required for the inflammatory phenotype.
Neg (not) Positive_regulation (required) of CD8 in T cells associated with targeted disruption and inflammation
4) Confidence 0.06 Published 2010 Journal Immunol. Rev. Section Abstract Doc Link 20193000 Disease Relevance 0.42 Pain Relevance 0.08
Hereafter, cells were washed, centrifuged and surface-stained for 30 minutes at 4°C in the dark with the following primary mouse anti rat antibodies: biotin conjugated CD5 (OX191), phycoerythrin (PE) labelled CD8 (OX82), fluorescein-isothiocyanate (FITC) labelled CD4 (OX382), CD45RA-PE (OX331), and HIS481.
Positive_regulation (labelled) of CD8
5) Confidence 0.04 Published 2008 Journal Respir Res Section Body Doc Link PMC2335107 Disease Relevance 0.05 Pain Relevance 0
Finally, the elevated levels of CD5+CD4+ and CD5+CD8+ may be explained by their possible role in the pathogenesis of lung fibrosis, which is also supported by the presence of macrophages in the BALf and lung parenchyma of ischemic animals 3, 7, and 90 days after reperfusion, since they are also thought to be important mediators in the regulation of fibroblast function [37,38,57,58].
Positive_regulation (elevated) of CD8 in lung associated with fibrosis and pulmonary fibrosis
6) Confidence 0.04 Published 2008 Journal Respir Res Section Body Doc Link PMC2335107 Disease Relevance 0.50 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox