INT166673

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Context Info
Confidence 0.36
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PRKCA, UGT1A6) endoplasmic reticulum (PRKCA, UGT1A6) enzyme binding (PRKCA, UGT1A6)
nucleoplasm (PRKCA) mitochondrion (PRKCA) cytoplasm (PRKCA)
PRKCA (Homo sapiens)
UGT1A6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 13 100.00 Very High Very High Very High
Paracetamol 3 97.52 Very High Very High Very High
Serotonin 3 94.96 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The potential for PKC-mediated inhibition of human UGT1A6, an isoform involved in the glucuronidation of drugs such as acetaminophen (paracetamol) and endogenous substrates including serotonin, was evaluated using various cell model systems.
PKC Negative_regulation (inhibition) of UGT1A6 associated with paracetamol, kinase c and serotonin
1) Confidence 0.36 Published 2010 Journal Xenobiotica Section Abstract Doc Link 20196639 Disease Relevance 0 Pain Relevance 0.69

General Comments

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