INT166678

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Context Info
Confidence 0.38
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 5.77
Pain Relevance 4.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PRKCA) mitochondrion (PRKCA) small molecule metabolic process (PRKCA)
endoplasmic reticulum (PRKCA) enzyme binding (PRKCA) cytoplasm (PRKCA)
Anatomy Link Frequency
neuronal 10
neurons 8
PRKCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 622 100.00 Very High Very High Very High
Calcium channel 28 99.58 Very High Very High Very High
agonist 89 99.18 Very High Very High Very High
Neuronal excitability 18 98.72 Very High Very High Very High
imagery 32 88.00 High High
Neurotransmitter 15 85.60 High High
Paracetamol 3 84.32 Quite High
Serotonin 11 79.20 Quite High
Hippocampus 22 76.56 Quite High
Central nervous system 90 74.88 Quite High
Disease Link Frequency Relevance Heat
Virus Diseases 801 99.80 Very High Very High Very High
Infection 267 99.58 Very High Very High Very High
Rabies Virus Infection 9 96.96 Very High Very High Very High
Cognitive Disorder 29 78.32 Quite High
Borna Disease 36 75.00 Quite High
INFLAMMATION 39 69.48 Quite High
Neurological Disease 36 67.60 Quite High
Disease 56 61.92 Quite High
Endometriosis (extended) 4 41.40 Quite Low
Hot Flashes 20 40.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with our previous reports, we showed by quantitative Western blot analysis that the phosphorylation of these two neuronal PKC targets was significantly impaired in neurons infected with rBDV-wt (Figure 2A and 2B).
Negative_regulation (impaired) of Phosphorylation (phosphorylation) of PKC in neurons associated with kinase c
1) Confidence 0.38 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.30 Pain Relevance 0.33
Moreover, the selective impairment of neuronal plasticity due to BDV infection was correlated to a reduced phosphorylation of the neuronal targets of Protein Kinase C (PKC), a kinase that plays important roles in the regulation of neuronal activity [25].
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of PKC in neuronal associated with virus diseases, kinase c and infection
2) Confidence 0.38 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 1.54 Pain Relevance 0.31
In theory, other viral phosphoproteins could also block endogenous phosphorylation, including that of PKC.
Negative_regulation (block) of Phosphorylation (phosphorylation) of PKC associated with kinase c
3) Confidence 0.38 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.87 Pain Relevance 0.27
Inhibition of UGT phosphorylation by PKC inhibitor drugs may represent a novel mechanism for drug-drug interactions.
Negative_regulation (Inhibition) of Phosphorylation (phosphorylation) of PKC associated with kinase c
4) Confidence 0.33 Published 2010 Journal Xenobiotica Section Abstract Doc Link 20196639 Disease Relevance 0 Pain Relevance 0.61
Together, these findings suggest that BDV mediated interference with PKC-dependent phosphorylation, by reducing phospho-SNAP-25 levels, leads to calcium hyper-responsiveness and that mutation of the BDV P phosphorylation sites restores normal calcium responses.


Negative_regulation (interference) of Phosphorylation (phosphorylation) of PKC-dependent associated with virus diseases and kinase c
5) Confidence 0.28 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.28 Pain Relevance 0.21
Taken together, these observations led us to postulate that BDV P may serve as a PKC kinase decoy substrate when expressed in neurons, resulting in the decreased phosphorylation of other PKC neuronal targets.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of PKC in neuronal associated with virus diseases and kinase c
6) Confidence 0.28 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.83 Pain Relevance 0.31
Therefore, preventing P phosphorylation by PKC abolishes viral interference with neuronal activity in response to stimulation.
Negative_regulation (abolishes) of Phosphorylation (phosphorylation) of PKC in neuronal associated with kinase c
7) Confidence 0.27 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2673689 Disease Relevance 0.53 Pain Relevance 0.46
Therefore, preventing P phosphorylation by PKC abolishes viral interference with neuronal activity in response to stimulation.
Negative_regulation (preventing) of Phosphorylation (phosphorylation) of PKC in neuronal associated with kinase c
8) Confidence 0.27 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2673689 Disease Relevance 0.53 Pain Relevance 0.46
Indeed, PKC phosphorylation of SNAP-25, by promoting inhibition of VGCCs decreases calcium signaling and controls neuronal excitability.
Negative_regulation (decreases) of Phosphorylation (phosphorylation) of PKC in neuronal associated with kinase c and neuronal excitability
9) Confidence 0.27 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.07 Pain Relevance 0.32
Moreover, neurons infected with this mutant virus exhibited a normal pattern of phosphorylation of the PKC endogenous substrates MARCKS and SNAP-25.
Negative_regulation (pattern) of Phosphorylation (phosphorylation) of PKC in neurons associated with kinase c
10) Confidence 0.27 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2673689 Disease Relevance 0.83 Pain Relevance 0.50
Our initial studies indicated that DAG-dependent PKC isoforms are involved in the response since PMA was able to mimic the effect of PAR2 activation, abolishing both JNK activity and phosphorylation.
Negative_regulation (abolishing) of Phosphorylation (phosphorylation) of PKC
11) Confidence 0.09 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0 Pain Relevance 0.13
agonists also increased calcium oscillations and phosphorylated PKC, AKT and ERK1/2 in neurons derived from mouse ES cells, which was inhibited by nifedipine demonstrating that ER?
Negative_regulation (inhibited) of Phosphorylation (phosphorylated) of PKC in neurons associated with agonist
12) Confidence 0.06 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2910705 Disease Relevance 0 Pain Relevance 0.26
The activation of these pathways in neurons from mES cells is dependent on calcium mobilization from L-type VGCC, because nifedipine blocks the increase in calcium oscillations and the phosphorylation of PKC, Raf-1 and AKT.
Negative_regulation (blocks) of Phosphorylation (phosphorylation) of PKC in neurons associated with kinase c and calcium channel
13) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910705 Disease Relevance 0 Pain Relevance 0.43

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