INT16669

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Context Info
Confidence 0.26
First Reported 1991
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.70
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CNDP2) peptidase activity (CNDP2) small molecule metabolic process (CNDP2)
cellular nitrogen compound metabolic process (CNDP2) cytoplasm (CNDP2)
Anatomy Link Frequency
epithelial cells 3
CNDP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 5 99.42 Very High Very High Very High
bDMF 21 96.72 Very High Very High Very High
Inflammation 9 91.20 High High
depression 1 84.96 Quite High
rheumatoid arthritis 54 83.92 Quite High
long-term potentiation 1 79.36 Quite High
corticosteroid 2 77.24 Quite High
Leflunomide 2 73.72 Quite High
methotrexate 2 70.72 Quite High
Migraine 1 66.12 Quite High
Disease Link Frequency Relevance Heat
Ehrlichiosis 23 91.52 High High
INFLAMMATION 10 91.20 High High
Diabetes Mellitus 16 88.04 High High
Depression 1 84.96 Quite High
Disease 153 84.56 Quite High
Rheumatoid Arthritis 54 83.92 Quite High
Necrosis 2 74.60 Quite High
Cancer 5 74.24 Quite High
Cardiovascular Disease 33 71.24 Quite High
Headache 2 66.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, TrkB and serpin peptidase inhibitor, clade e (nexin, plasminogen activator inhibitor type 1), member 2 (SERPINE2) were present in the set of 1,663 genes and located in module 1.
Gene_expression (present) of peptidase
1) Confidence 0.26 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.62 Pain Relevance 0.60
Glucocorticoids do not alter peptidase expression on a human bronchial epithelial cell line.
Gene_expression (expression) of peptidase in epithelial cell associated with enkephalin
2) Confidence 0.20 Published 1994 Journal Am. J. Respir. Cell Mol. Biol. Section Title Doc Link 7517143 Disease Relevance 0.09 Pain Relevance 0.15
Detection of anti-pepA and anti-pepB antibodies by line immunoassay
Gene_expression (Detection) of pepA
3) Confidence 0.19 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779401 Disease Relevance 0.64 Pain Relevance 0.24
Using an immortalized bronchial epithelial cell line (BEAS-2B), we have shown that human epithelial cells express no detectable angiotensin-converting enzyme, carboxypeptidase N, or dipeptidyl(amino)peptidase IV, but express significant levels of aminopeptidase M (AmM), as well as NEP-24.11.
Neg (no) Gene_expression (express) of peptidase in epithelial cells
4) Confidence 0.18 Published 1994 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 7517143 Disease Relevance 0.09 Pain Relevance 0.04
Using an immortalized bronchial epithelial cell line (BEAS-2B), we have shown that human epithelial cells express no detectable angiotensin-converting enzyme, carboxypeptidase N, or dipeptidyl(amino)peptidase IV, but express significant levels of aminopeptidase M (AmM), as well as NEP-24.11.
Neg (no) Gene_expression (detectable) of peptidase in epithelial cells
5) Confidence 0.15 Published 1994 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 7517143 Disease Relevance 0.09 Pain Relevance 0.04
Neutral endopeptidase (NEP, also known as enkephalinase, CALLA, or EC 3.4.24.11) is a membrane-bound peptidase present in many different cell types.
Gene_expression (present) of peptidase
6) Confidence 0.08 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1847594 Disease Relevance 0 Pain Relevance 0.05
These ortholog clusters include genes for amino acid, fatty acid and nucleotide biosynthesis, an M48 family peptidase, a cytochrome c-type biogenesis protein, and the type IV secretion system protein VirB4 (Table S6).
Gene_expression (biosynthesis) of peptidase
7) Confidence 0.01 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1366493 Disease Relevance 0.17 Pain Relevance 0
Although no other peptidase activities were detectable in purified or semi-purified proteins, activity assays with wild type His-rAp-B enzyme were performed as described above.


Gene_expression (detectable) of peptidase
8) Confidence 0.01 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2241622 Disease Relevance 0 Pain Relevance 0

General Comments

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