INT166700

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Context Info
Confidence 0.73
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 3.33
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (RNH1)
Anatomy Link Frequency
thyroid 1
RNH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 8 88.96 High High
withdrawal 188 81.48 Quite High
Pain 5 66.20 Quite High
fibrosis 1 64.00 Quite High
cva 4 61.44 Quite High
headache 4 43.12 Quite Low
positron emission tomography 28 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 84 99.26 Very High Very High Very High
Malignant Neoplastic Disease 8 97.40 Very High Very High Very High
Cancer 48 97.20 Very High Very High Very High
Thyroid Neoplasm 128 93.68 High High
Thyroid Disease 32 91.04 High High
Metastasis 56 90.64 High High
Endometriosis (extended) 8 88.96 High High
Recurrence 20 71.04 Quite High
Pain 4 66.20 Quite High
Pressure And Volume Under Development 8 64.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Abundance or localization changes in endometrial tissue were validated by immunohistochemistry and Western blotting for three proteins, vimentin (VIM), peroxiredoxin 6 (PRDX6), and ribonuclease/angiogenin inhibitor 1 (RNH1), while observed changes could not be confirmed for coronin 1A (CORO1A) or transgelin (TAGLN2).
Localization (blotting) of ribonuclease/angiogenin inhibitor 1
1) Confidence 0.73 Published 2010 Journal J. Proteome Res. Section Abstract Doc Link 20199104 Disease Relevance 0.64 Pain Relevance 0.36
The use of RAI for all three purposes relies on the ability of both normal and malignant thyroid tissue to transport iodine for synthesis of thyroglobulin, triiodothyronine and thyroxine in response to TSH.
Localization (use) of RAI in thyroid associated with malignant neoplastic disease
2) Confidence 0.17 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994210 Disease Relevance 0.83 Pain Relevance 0.12
Since there is reduced renal clearance of iodine and longer retention of the RAI in hypothyroid patients, preparation with rhTSH allows patients to remain euthyroid and potentially clear their radiation dose faster.
Localization (retention) of RAI
3) Confidence 0.15 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994210 Disease Relevance 1.11 Pain Relevance 0.15
Traditionally, follow-up surveillance RAI WBS and stimulated thyroglobulin (Tg) measurements (Figure 2) are performed every 12 months after remnant ablation for several years and then periodically.
Localization (measurements) of RAI WBS
4) Confidence 0.15 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994210 Disease Relevance 0.30 Pain Relevance 0.03
It should be noted, that the patients who participated in these studies were generally patients with low stage disease, and because of concern about lower RAI uptake from early studies with rhTSH, care should be taken when evaluating patients for selection for rhTSH stimulated ablation.


Localization (uptake) of RAI associated with disease
5) Confidence 0.15 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994210 Disease Relevance 0.46 Pain Relevance 0.07

General Comments

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