INT166708

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Context Info
Confidence 0.32
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.62
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Col7a1) cell adhesion (Col7a1) proteinaceous extracellular matrix (Col7a1)
Anatomy Link Frequency
cartilage 2
Col7a1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 27 100.00 Very High Very High Very High
fibrosis 38 99.92 Very High Very High Very High
Osteoarthritis 11 98.88 Very High Very High Very High
Inflammation 36 97.56 Very High Very High Very High
Pain 2 71.28 Quite High
Bile 2 23.16 Low Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 1 100.00 Very High Very High Very High
Cirrhosis 15 99.92 Very High Very High Very High
Osteoarthritis 11 98.88 Very High Very High Very High
Fibrosis 51 98.24 Very High Very High Very High
INFLAMMATION 39 97.56 Very High Very High Very High
Necrosis 11 95.80 Very High Very High Very High
Sprains And Strains 2 91.40 High High
Hyperplasia 1 88.72 High High
Liver Disease 4 82.96 Quite High
Osteophyte 1 73.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of OA cartilage damage was afforded by mutations that either reduced chondrocyte hypertrophy or abrogated proteolysis of aggrecan and collagen II in cartilage.
Negative_regulation (reduced) of Protein_catabolism (proteolysis) of collagen in cartilage associated with hypertrophy and osteoarthritis
1) Confidence 0.32 Published 2010 Journal Curr Drug Targets Section Abstract Doc Link 20199393 Disease Relevance 1.30 Pain Relevance 0.41
Inhibition of MMPs and collagen degradation by Marimastat, however, counterbalanced the beneficial anti-inflammatory effect, resulting in a positive balance of collagen deposition.
Negative_regulation (Inhibition) of Protein_catabolism (degradation) of collagen associated with inflammation and metalloproteinase
2) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 1.31 Pain Relevance 0.51

General Comments

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