INT16671

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Context Info
Confidence 0.30
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 4.80
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MBTPS1) Golgi apparatus (MBTPS1) endoplasmic reticulum (MBTPS1)
lipid metabolic process (MBTPS1)
Anatomy Link Frequency
cleavage 2
plasma 1
artery 1
immune cells 1
MBTPS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 1 96.88 Very High Very High Very High
Inflammatory response 1 88.40 High High
bradykinin 2 84.56 Quite High
substance P 1 84.08 Quite High
Enkephalin 3 83.16 Quite High
Inflammation 14 63.20 Quite High
Pain 62 61.84 Quite High
rheumatoid arthritis 8 60.80 Quite High
Multiple sclerosis 4 43.84 Quite Low
imagery 46 34.56 Quite Low
Disease Link Frequency Relevance Heat
Oxyphilic Adenoma 1 99.44 Very High Very High Very High
Renal Cell Carcinoma 1 99.14 Very High Very High Very High
Hepatocellular Cancer 4 99.00 Very High Very High Very High
Renal Cancer 39 98.28 Very High Very High Very High
Fabry Disease 384 97.84 Very High Very High Very High
Leukemia 4 97.28 Very High Very High Very High
INFLAMMATION 19 96.88 Very High Very High Very High
Renal Disease 52 90.52 High High
Chronic Lymphoid Leukemia 2 89.48 High High
Injury 8 85.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Remarkably, seabass BDNF does not contain the cleavage site (RGLT) that in mammals is recognized by the Membrane-bound transcription factor site-1 protease (MBTPS1 also known as SKI-1 protease) to generate the pro28KDa-BDNFisoforms after a cleavage at Threonin 57 [51].
Gene_expression (protease) of SKI-1 in cleavage
1) Confidence 0.30 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829032 Disease Relevance 0.30 Pain Relevance 0
Remarkably, seabass BDNF does not contain the cleavage site (RGLT) that in mammals is recognized by the Membrane-bound transcription factor site-1 protease (MBTPS1 also known as SKI-1 protease) to generate the pro28KDa-BDNFisoforms after a cleavage at Threonin 57 [51].
Gene_expression (protease) of MBTPS1 in cleavage
2) Confidence 0.30 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829032 Disease Relevance 0.30 Pain Relevance 0
Following numerous reports of the role of sphingolipid metabolite, S1P, in a variety of cellular processes, such as cell differentiation and proliferation, we investigated if decreasing the production of S1P, by knocking down SPHK expression, would affect the immune cells response to inflammatory mediators.
Gene_expression (production) of S1P in immune cells associated with inflammatory mediators
3) Confidence 0.25 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 0.63 Pain Relevance 0.12
Neutral endopeptidase (NEP, also known as enkephalinase, CALLA, or EC 3.4.24.11) is a membrane-bound peptidase present in many different cell types.
Gene_expression (present) of endopeptidase
4) Confidence 0.25 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1847594 Disease Relevance 0 Pain Relevance 0.05
Moreover, there was a strong correlation between plasma S1P levels and LVM index, and increased common carotide artery IMT in patients with FD [285].
Gene_expression (levels) of S1P in artery associated with fabry disease
5) Confidence 0.13 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3009617 Disease Relevance 1.06 Pain Relevance 0.09
Male patients had significantly higher plasma S1P levels compared with healthy controls.
Gene_expression (levels) of S1P in plasma
6) Confidence 0.11 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3009617 Disease Relevance 0.99 Pain Relevance 0.08
CALLA: (common acute lymphoblastic leukemia antigen); CCRCC: (clear-cell renal cell carcinoma); ChRCC: (chromophobe renal cell carcinoma); DPPIV: (dipeptidyl peptidase IV); NEP: (neprilysine, neutral endopeptidase); RO: (renal oncocytoma); UP: (Units of Peptidase, pmol of product/min).


Gene_expression (neprilysine) of endopeptidase associated with leukemia, renal cancer, renal cell carcinoma and oxyphilic adenoma
7) Confidence 0.05 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 1.15 Pain Relevance 0
Increased expression of neprilysin (neutral endopeptidase 24.11) in rat and human hepatocellular carcinomas.
Gene_expression (expression) of endopeptidase associated with hepatocellular cancer
8) Confidence 0.02 Published 1994 Journal Lab. Invest. Section Title Doc Link 8302012 Disease Relevance 0.37 Pain Relevance 0.17

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