INT166710

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.46
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.72
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (CFTR) ATPase activity (CFTR) plasma membrane (CFTR)
enzyme binding (CFTR) protein complex (CFTR) transmembrane transport (CFTR)
Anatomy Link Frequency
epithelial cell 6
kidney 2
CFTR (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 97 100.00 Very High Very High Very High
fibrosis 62 100.00 Very High Very High Very High
cytokine 105 99.64 Very High Very High Very High
Analgesic 1 92.36 High High
Bioavailability 2 87.12 High High
Inflammation 179 80.24 Quite High
abdominal pain 9 69.08 Quite High
sodium channel 45 62.80 Quite High
Inflammatory mediators 100 46.52 Quite Low
chemokine 10 37.52 Quite Low
Disease Link Frequency Relevance Heat
Pancreatitis 138 100.00 Very High Very High Very High
Cystic Fibrosis 61 100.00 Very High Very High Very High
Exocrine Pancreatic Insufficiency 12 98.68 Very High Very High Very High
Failure To Thrive 1 90.92 High High
Mental Disorders 4 88.00 High High
Sepsis 22 86.28 High High
INFLAMMATION 289 80.24 Quite High
Bronchiectasis 1 78.72 Quite High
Ileus 1 74.80 Quite High
Congenital Anomalies 21 70.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glafenine increased the surface expression of Delta Phe508-CFTR in baby hamster kidney (BHK) cells to approximately 40% of that observed for wild-type CFTR, comparable with the known CFTR corrector 4-cyclohexyloxy-2-{1-[4-(4-methoxybenzensulfonyl)-piperazin-1-yl]-ethyl}-quinazoline (VRT-325).
Positive_regulation (increased) of Gene_expression (expression) of CFTR in kidney
1) Confidence 0.46 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20200141 Disease Relevance 0.26 Pain Relevance 0.31
Another cytokine, which was found to increase CFTR expression in human bronchial epithelial cells is IL-1 beta and this was associated with an increase in short circuit current in the Ussing chambers [24].
Positive_regulation (increase) of Gene_expression (expression) of CFTR in epithelial cells associated with cytokine
2) Confidence 0.41 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0 Pain Relevance 0.10
This cytokine is also a potent upregulator of CFTR protein expression and function in vitro [49,50].
Positive_regulation (upregulator) of Gene_expression (expression) of CFTR protein associated with cytokine
3) Confidence 0.41 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0 Pain Relevance 0.10
G542X is a Class I mutation that results in the complete failure to synthesize functional cystic fibrosis transmembrane conductance regulator (CFTR) and is usually associated with pancreatic insufficiency.
Positive_regulation (conductance) of Neg (failure) Gene_expression (synthesize) of CFTR associated with fibrosis, exocrine pancreatic insufficiency and cystic fibrosis
4) Confidence 0.37 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2936924 Disease Relevance 1.39 Pain Relevance 0.35
CFTR mutations in chronic pancreatitis
Positive_regulation (pancreatitis) of Gene_expression (mutations) of CFTR associated with chronic pancreatitis
5) Confidence 0.33 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.79 Pain Relevance 0.68
Expression of epithelial inducible nitric oxide synthase and NO production was reduced in a human trachea epithelial cell line where CFTR activity was blocked by the over-expression of the CFTR regulatory domain.
Positive_regulation (-) of Gene_expression (expression) of CFTR in epithelial cell
6) Confidence 0.27 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.44 Pain Relevance 0.22
Expression of epithelial inducible nitric oxide synthase and NO production was reduced in a human trachea epithelial cell line where CFTR activity was blocked by the over-expression of the CFTR regulatory domain.
Positive_regulation (over) of Gene_expression (expression) of CFTR in epithelial cell
7) Confidence 0.27 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.44 Pain Relevance 0.22
CFTR and CaCC seem to regulate each others activity: CFTR activation or increased expression is associated with a reduction in CaCC function.
Positive_regulation (increased) of Gene_expression (expression) of CFTR
8) Confidence 0.27 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.08 Pain Relevance 0.07
s for the two formats were adequate for all CHQ-CF scales, except “physical functioning–in the subgroup administered the paper version of the questionnaire (?
Positive_regulation (adequate) of Gene_expression (scales) of CHQ-CF
9) Confidence 0.27 Published 2007 Journal Qual Life Res Section Body Doc Link PMC1832149 Disease Relevance 0.31 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox