INT166715

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Context Info
Confidence 0.65
First Reported 2006
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 20
Disease Relevance 6.39
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sox9) signal transduction (Sox9) nucleus (Sox9)
extracellular matrix organization (Sox9) protein complex assembly (Sox9) DNA binding (Sox9)
Anatomy Link Frequency
melanocytes 2
chondrocytes 1
cartilage 1
bone marrow 1
neurons 1
Sox9 (Mus musculus)
Pain Link Frequency Relevance Heat
Snapping jaw 4 93.76 High High
Mechanotransduction 11 93.56 High High
cytokine 47 92.28 High High
chemokine 4 91.84 High High
Inflammation 113 90.16 High High
Osteoarthritis 81 83.52 Quite High
rheumatoid arthritis 70 50.72 Quite High
Kinase C 3 13.68 Low Low
Arthritis 34 5.00 Very Low Very Low Very Low
Pain 32 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colorectal Cancer 72 99.84 Very High Very High Very High
Breast Cancer 4 99.16 Very High Very High Very High
Sprains And Strains 39 99.00 Very High Very High Very High
Intervertebral Disk Degeneration 124 98.96 Very High Very High Very High
Inflammatory Bowel Disease 84 98.56 Very High Very High Very High
Adenoma 116 96.52 Very High Very High Very High
Targeted Disruption 226 94.64 High High
Temporomandibular Joint Syndrome 4 93.76 High High
Osteoporosis 115 91.92 High High
INFLAMMATION 114 90.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of Sox9, Runx2, and Osterix was low, as was that of collagen II, collagen I, and aggrecan, thus altering the fibrocartilaginous nature of the condyle.
Gene_expression (Expression) of Sox9 in condyle
1) Confidence 0.65 Published 2010 Journal J. Dent. Res. Section Abstract Doc Link 20200412 Disease Relevance 0.25 Pain Relevance 0.31
A decrease in Sox9 expression has been associated with disc degeneration (Gruber et al., 2005), suggesting that it could also be a potential therapeutic target.
Gene_expression (expression) of Sox9 associated with intervertebral disk degeneration
2) Confidence 0.59 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008962 Disease Relevance 0.22 Pain Relevance 0
The transcription factor Sox9, which is associated with chondrogenic differentiation and collagen II synthesis, is expressed throughout the disc structures during embryogenesis (Barrionuevo et al., 2006) and in the newborn AF (Gruber et al., 2005).
Gene_expression (expressed) of Sox9
3) Confidence 0.59 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008962 Disease Relevance 0.20 Pain Relevance 0
We found that physical stimuli produced a pattern of principal strain that precisely corresponded to the site-specific expression of sox9 and runx2, two transcription factors required for the commitment of stem cells to a skeletogenic lineage, and the arrangement and orientation of newly deposited type I collagen fibrils.
Gene_expression (expression) of sox9 in stem cells associated with sprains and strains
4) Confidence 0.57 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1849965 Disease Relevance 0.18 Pain Relevance 0.15
We also examined expression of SOX9 at 1 wk following fracture, and observed an up-regulation of this transcription factor in the ?
Spec (examined) Gene_expression (expression) of SOX9
5) Confidence 0.56 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1950214 Disease Relevance 0.33 Pain Relevance 0
SOX9 is a transcription factor for chondrogenic differentiation, and is expressed in chondroprogenitors and chondrocytes [33,34].
Gene_expression (expressed) of SOX9 in chondrocytes
6) Confidence 0.56 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1950214 Disease Relevance 0.31 Pain Relevance 0
SOX9 has been shown to be involved in the development and differentiation of many cell types and tissues, e.g. chondrocytes,[83] pancreatic tissue,[84] prostate,[85] testis[86] as well as melanocytes.[87] Furthermore, SOX9 is crucial for the development of intestinal epithelium since inactivation of SOX9 results in severe defects in differentiation of Paneth and Globlet cells.[88] There is growing evidence that SOX9 also plays an important role in different malignancies e.g. prostate, brain or breast cancer.[89–91] Recently, it has been shown that SOX9 is highly overexpressed in CRC[92] and overexpression is significantly associated with a lower five-year survival.[93] So far SOX9 expression has neither been reported in human UC-associated CRC or animal models like the DSS-AOM model of carcinogenesis.
Gene_expression (overexpressed) of SOX9 in melanocytes associated with colorectal cancer, inflammatory bowel disease and breast cancer
7) Confidence 0.52 Published 2010 Journal Journal of Carcinogenesis Section Body Doc Link PMC2862504 Disease Relevance 0.83 Pain Relevance 0.03
However, the expression of SOX9 and Cyclin-D1 – two key players of the Wnt signaling pathway – has been described for the first time in this model for UC-associated CRC.


Gene_expression (expression) of SOX9 associated with colorectal cancer and inflammatory bowel disease
8) Confidence 0.52 Published 2010 Journal Journal of Carcinogenesis Section Body Doc Link PMC2862504 Disease Relevance 1.15 Pain Relevance 0.08
The overall expression of SOX9 was less pronounced, leading to IRS between 0.7 to 2.0 as indicated in Figure 3c.
Gene_expression (expression) of SOX9
9) Confidence 0.52 Published 2010 Journal Journal of Carcinogenesis Section Body Doc Link PMC2862504 Disease Relevance 0.68 Pain Relevance 0
SOX9 has been shown to be involved in the development and differentiation of many cell types and tissues, e.g. chondrocytes,[83] pancreatic tissue,[84] prostate,[85] testis[86] as well as melanocytes.[87] Furthermore, SOX9 is crucial for the development of intestinal epithelium since inactivation of SOX9 results in severe defects in differentiation of Paneth and Globlet cells.[88] There is growing evidence that SOX9 also plays an important role in different malignancies e.g. prostate, brain or breast cancer.[89–91] Recently, it has been shown that SOX9 is highly overexpressed in CRC[92] and overexpression is significantly associated with a lower five-year survival.[93] So far SOX9 expression has neither been reported in human UC-associated CRC or animal models like the DSS-AOM model of carcinogenesis.
Gene_expression (expression) of SOX9 in melanocytes associated with colorectal cancer, inflammatory bowel disease and breast cancer
10) Confidence 0.52 Published 2010 Journal Journal of Carcinogenesis Section Body Doc Link PMC2862504 Disease Relevance 0.83 Pain Relevance 0.04
However, SOX9 was down-regulated in ?
Gene_expression (was) of SOX9
11) Confidence 0.49 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1950214 Disease Relevance 0.40 Pain Relevance 0
Sox9 is expressed in all primordial cartilage during embryogenesis, coincident with collagen II expression (Bi et al., 1999), including in the sclerotome and notochord (Barrionuevo et al., 2006).
Gene_expression (expressed) of Sox9 in cartilage
12) Confidence 0.45 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008962 Disease Relevance 0.09 Pain Relevance 0
Although both cell types have been found to express the typical chondrogenic markers aggrecan, collagen II and Sox9 to a similar extent (Chen et al., 2006; Kim et al., 2009; Sive et al., 2002), the relative expression of collagen I, as well as biglycan, decorin and lumican, which are small leucine-rich proteoglycans that are important for collagen fibrillogenesis, is higher for mature NP cells than notochordal cells (Chen et al., 2006).
Gene_expression (express) of Sox9
13) Confidence 0.45 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008962 Disease Relevance 0.07 Pain Relevance 0
Sox9 expression is maintained in Müller cells but lost in maturing neurons [25].
Gene_expression (expression) of Sox9 in neurons
14) Confidence 0.44 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719914 Disease Relevance 0 Pain Relevance 0
Sox9 is a transcription factor that is widely expressed in retinal progenitor cells during development.
Gene_expression (expressed) of Sox9
15) Confidence 0.44 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719914 Disease Relevance 0 Pain Relevance 0
PPi appears to directly regulate expression of certain genes (including inductive effects first described by us for osteopontin and MMP-13 expression and suppressive effects on Sox9 expression)[18, 33–35].
Gene_expression (expression) of Sox9
16) Confidence 0.37 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.53 Pain Relevance 0.08
We also double-labeled P7 retinal sections for Clrn1 ISH and Sox9 immunohistochemistry (Figure 3G–3J).
Gene_expression (sections) of Sox9
17) Confidence 0.33 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719914 Disease Relevance 0 Pain Relevance 0
In bone marrow-derived MSCs, expression of exogenous sox9 led to increased proteoglycan deposition [18].
Gene_expression (expression) of sox9 in bone marrow
18) Confidence 0.23 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592798 Disease Relevance 0 Pain Relevance 0.09
Furthermore, significantly higher levels of Sox9, a chondrogenic transcription factor, were expressed in PTSCs and ATSCs than in control cells (Figure 3A, B, columns 5 and 6).
Gene_expression (expressed) of Sox9
19) Confidence 0.20 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2822826 Disease Relevance 0.09 Pain Relevance 0
Elements including activations of various intracellular signaling pathways (mitogen-activated protein kinases and Smads) and transcription factors (sox9, L-sox5, and L-sox6), production and interaction with extracellular matrix (ECM) proteins (collagen type II, aggrecan, and cartilage oligomeric matrix protein), activities of soluble bioactive factors such as growth factors, cytokines, chemokines, and hormones, and effects of environmental factors such as mechanical loading and oxygen tension all affect chondrogenic differentiation of MSCs (Figure 2).
Gene_expression (production) of sox9 in extracellular matrix associated with chemokine and cytokine
20) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592798 Disease Relevance 0.23 Pain Relevance 0.14

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