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Context Info
Confidence 0.26
First Reported 1987
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 1.45
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MBTPS1) Golgi apparatus (MBTPS1) endoplasmic reticulum (MBTPS1)
lipid metabolic process (MBTPS1)
Anatomy Link Frequency
cleavage 1
respiratory 1
MBTPS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 14 98.96 Very High Very High Very High
Endogenous opioid 1 98.52 Very High Very High Very High
Analgesic 10 96.60 Very High Very High Very High
Morphine 2 95.76 Very High Very High Very High
Pain 6 94.24 High High
Inflammation 39 93.44 High High
depression 2 89.36 High High
tolerance 6 88.40 High High
antidepressant 2 87.12 High High
Opioid 1 84.40 Quite High
Disease Link Frequency Relevance Heat
Injury 8 98.28 Very High Very High Very High
Cough 9 94.44 High High
Pain 5 94.24 High High
INFLAMMATION 41 93.44 High High
Constipation 1 90.04 High High
Respiratory Failure 1 89.36 High High
Asthma 2 71.84 Quite High
Bacterial Infection 1 66.56 Quite High
Bronchitis 7 58.20 Quite High
Appetite Loss 13 54.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The discovery that the endogenous opioid peptides, enkephalins, are inactivated by two metallopeptidases, neutral endopeptidase and aminopeptidase N, which can be blocked by synthetic dual inhibitors, represents a promising way to develop 'physiological' analgesics devoid of morphine side effects.
Negative_regulation (blocked) of endopeptidase associated with analgesic, endogenous opioid, enkephalin and morphine
1) Confidence 0.26 Published 2007 Journal Expert Opin. Ther. Targets Section Abstract Doc Link 17227231 Disease Relevance 0.53 Pain Relevance 1.35
More recent studies have demonstrated that reductions in neutral endopeptidase activity in animal airways is associated with increased responses to exogenously applied and endogenously released peptides.
Negative_regulation (reductions) of endopeptidase
2) Confidence 0.25 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1847594 Disease Relevance 0 Pain Relevance 0.07
The latter cleavage appeared reminiscent of endopeptidase since this peptidase was reported to cleave neurotensin at the Arg8-Arg9 bond.
Spec (appeared) Negative_regulation (reminiscent) of endopeptidase in cleavage
3) Confidence 0.19 Published 1996 Journal Brain Res. Section Abstract Doc Link 8869556 Disease Relevance 0 Pain Relevance 0.19
Our study indicated that neurotensin(1-10) formation by porcine endopeptidase could be potently blocked with the selective endopeptidase dipeptide inhibitor Pro-Ile without interfering with neurotensin(1-8) formation.
Negative_regulation (blocked) of endopeptidase
4) Confidence 0.19 Published 1996 Journal Brain Res. Section Abstract Doc Link 8869556 Disease Relevance 0 Pain Relevance 0.17
Dipeptidyl aminopeptidase was inhibited by angiotensins II and III and their derivatives, whereas the endopeptidase was inhibited by angiotensin I and its derivatives.
Negative_regulation (inhibited) of endopeptidase
5) Confidence 0.03 Published 1987 Journal J. Neurochem. Section Abstract Doc Link 3037031 Disease Relevance 0 Pain Relevance 0.53
It has been repeatedly demonstrated in both human and animal studies that neutral endopeptidase levels are reduced in the presence of respiratory epithelial injury and associated bronchial hyper-responsiveness (Cheung et al 1992; Cheung et al 1993).
Negative_regulation (reduced) of endopeptidase in respiratory associated with injury
6) Confidence 0.01 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650606 Disease Relevance 0.80 Pain Relevance 0.15
Inactivation of prohormone convertase 1/3 (a preproghrelin endopeptidase) also increases ghrelin gene transcripts, suggesting negative feedback by ghrelin on its own transcription [496].
Negative_regulation (Inactivation) of endopeptidase
7) Confidence 0.01 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.12 Pain Relevance 0

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