INT166720

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.84
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rxrb)
Rxrb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 132 98.58 Very High Very High Very High
Inflammation 26 93.08 High High
Potency 12 90.96 High High
member 8 1 86.48 High High
Inflammatory stimuli 4 80.64 Quite High
cytokine 22 76.52 Quite High
Arthritis 22 73.36 Quite High
rheumatoid arthritis 36 57.76 Quite High
anesthesia 2 24.80 Low Low
ketamine 2 23.84 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 32 93.08 High High
Hypercalcemia 4 90.12 High High
Osteoporosis 3 86.36 High High
Experimental Arthritis 12 73.36 Quite High
Arthritis 16 62.84 Quite High
Rheumatoid Arthritis 38 57.76 Quite High
Pressure And Volume Under Development 2 49.00 Quite Low
Disease 8 42.84 Quite Low
Osteoarthritis 2 37.84 Quite Low
Cancer 6 29.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, we also failed to demonstrate any potentiation of the suppressive effect of ATRA on IL-6 when it was used in combination with BMS-649, suggesting that activation of RXR played a minor role.
Positive_regulation (activation) of RXR associated with agonist
1) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0.17 Pain Relevance 0.65
First, we used compounds acting either on RAR or RXR, alone or in combination, to demonstrate that the downregulation of IL-6 was not dependent of RXR activation.
Positive_regulation (activation) of RXR
2) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0.35 Pain Relevance 0.40
This compound (VDRM2) potently induced Retinoid X Receptor alpha (RXR)-VDR heterodimerization (EC(50) = 7.1 +/- 1.6 nM) and induced osteocalcin promoter activity (EC(50) = 1.9 +/- 1.6 nM).
Positive_regulation (induced) of RXR
3) Confidence 0.14 Published 2010 Journal J. Bone Miner. Res. Section Abstract Doc Link 20200930 Disease Relevance 0.31 Pain Relevance 0.09

General Comments

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