INT166724

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Context Info
Confidence 0.28
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.32
Pain Relevance 0.09

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aging (Vdr, Rxra) DNA binding (Vdr, Rxra) nucleus (Vdr, Rxra)
nuclear chromosome (Vdr) cell morphogenesis (Vdr) enzyme binding (Rxra)
Vdr (Rattus norvegicus)
Rxra (Rattus norvegicus)
Pain Link Frequency Relevance Heat
member 8 1 88.40 High High
Disease Link Frequency Relevance Heat
Hypercalcemia 4 89.80 High High
Osteoporosis 1 86.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This compound (VDRM2) potently induced Retinoid X Receptor alpha (RXR)-VDR heterodimerization (EC(50) = 7.1 +/- 1.6 nM) and induced osteocalcin promoter activity (EC(50) = 1.9 +/- 1.6 nM).
VDR Binding (heterodimerization) of Retinoid X Receptor alpha
1) Confidence 0.28 Published 2010 Journal J. Bone Miner. Res. Section Abstract Doc Link 20200930 Disease Relevance 0.32 Pain Relevance 0.09

General Comments

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