INT166734

Context Info Confidence 0.04 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.45 Pain Relevance 0.06

isomerase activity (PPIL1) protein folding (PPIL1) nucleus (BATF)

BATF (Homo sapiens) PPIL1 (Homo sapiens)

Pain Link Frequency Relevance Heat palliative 1 56.56

Disease Link Frequency Relevance Heat Glioma 7 100.00 Apoptosis 4 100.00 Hypoxia 1 99.04 Glioblastoma 1 94.64 Death 2 83.60 Cancer 2 74.84 Brain Tumor 1 53.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In conclusion, CsA or SFA in combination with cisplatin synergistically enhances cisplatin-induced apoptosis in C6 glioma cells via inhibition of PPIase activity of CypA, indicating that development of new drugs that selectively inhibit the CypA PPIase activity without immune suppression may facilitate alleviation of chemoresistance in treatment of high-grade glioma.

SFA Negative_regulation (inhibition) of PPIase associated with apoptosis and glioma

1) Confidence 0.04 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20204291 Disease Relevance 1.45 Pain Relevance 0.06

General Comments

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