INT166738

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.20
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (PPIA) isomerase activity (PPIA) protein folding (PPIA)
cytosol (PPIA) extracellular region (PPIA) nucleus (PPIA)
PPIA (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 1 48.28 Quite Low
Disease Link Frequency Relevance Heat
Glioma 7 97.84 Very High Very High Very High
Apoptosis 4 97.58 Very High Very High Very High
Hypoxia 1 90.76 High High
Glioblastoma 1 86.36 High High
Death 2 75.32 Quite High
Cancer 2 66.56 Quite High
Brain Tumor 1 45.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, CsA or SFA in combination with cisplatin synergistically enhances cisplatin-induced apoptosis in C6 glioma cells via inhibition of PPIase activity of CypA, indicating that development of new drugs that selectively inhibit the CypA PPIase activity without immune suppression may facilitate alleviation of chemoresistance in treatment of high-grade glioma.
Negative_regulation (inhibit) of CypA associated with apoptosis and glioma
1) Confidence 0.42 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20204291 Disease Relevance 1.20 Pain Relevance 0

General Comments

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