INT166745

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Context Info
Confidence 0.52
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 13
Disease Relevance 13.52
Pain Relevance 2.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL32) extracellular region (IL32) cell adhesion (IL32)
Anatomy Link Frequency
poly 3
leukocyte 1
lung 1
IL32 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 372 100.00 Very High Very High Very High
Inflammatory response 84 97.28 Very High Very High Very High
cytokine 60 94.32 High High
aspirin 84 71.84 Quite High
COX-2 inhibitor 36 70.48 Quite High
interstitial cystitis 2 50.00 Quite Low
rheumatoid arthritis 12 48.24 Quite Low
cINOD 60 14.96 Low Low
withdrawal 12 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 492 100.00 Very High Very High Very High
Infection 300 99.98 Very High Very High Very High
Influenza Virus Infection 528 99.84 Very High Very High Very High
Viral Infection 96 94.16 High High
Hepatitis 36 71.84 Quite High
Hepatitis B Virus Infection 12 70.32 Quite High
Hepatitis C Virus Infection 12 68.32 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 12 65.68 Quite High
Interstitial Cystitis 2 60.56 Quite High
Ulcers 2 59.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-32 was induced by influenza virus infection through COX-2-dependent mechanism.
Positive_regulation (induced) of IL-32 associated with influenza virus infection
1) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2288676 Disease Relevance 1.52 Pain Relevance 0.18
First, the effects of COX-2 on the activation of IL-32 promoter were determined.
Positive_regulation (activation) of IL-32 promoter
2) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2288676 Disease Relevance 0.90 Pain Relevance 0.20
COX-2 and IL-32 activation in response to influenza A virus infection and dsRNA treatment in a time-dependent manner
Positive_regulation (activation) of IL-32 associated with influenza virus infection and infection
3) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2288676 Disease Relevance 0.79 Pain Relevance 0
Furthermore, IL-32 accumulation in culture supernatants stimulated by poly(IC)+IFN-?
Positive_regulation (accumulation) of IL-32 in poly
4) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2288676 Disease Relevance 0 Pain Relevance 0.03
Comparing the IV infection induced IL-32 level in cell culture with that in human individuals, a significant difference between them was observed, over 10-fold increase in cell culture versus 58.2% in human individuals.
Positive_regulation (induced) of IL-32 associated with infection
5) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2288676 Disease Relevance 1.08 Pain Relevance 0.25
Activation of Interleukin-32 Pro-Inflammatory Pathway in Response to Influenza A Virus Infection

Background

Positive_regulation (Activation) of Interleukin-32 associated with inflammation, influenza virus infection and infection
6) Confidence 0.35 Published 2008 Journal PLoS ONE Section Title Doc Link PMC2288676 Disease Relevance 1.06 Pain Relevance 0.34
treatment in A549 human lung epithelial cells were able to induce COX-2/ IL-32 mRNA and protein expression as well as PGE2 and IL-32 accumulation in the cell culture supernatants.
Positive_regulation (accumulation) of IL-32 in lung
7) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2288676 Disease Relevance 1.52 Pain Relevance 0.18
, and NS1 are the most important factors in the induction of either COX-2 (Fig. 2A) or IL-32 (Fig. 2B) promoter activities, which means dsRNA and NS1 are the key viral components involved in IV-triggered COX-2 and IL-32 expression during viral infection.
Positive_regulation (induction) of IL-32 associated with viral infection
8) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2288676 Disease Relevance 1.17 Pain Relevance 0.16
Our results demonstrate that significant increase of serum COX-2-derived PGE2 and IL-32 levels were observed in influenza A infected patients compared with healthy individuals.
Positive_regulation (increase) of IL-32 associated with influenza virus infection
9) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2288676 Disease Relevance 1.47 Pain Relevance 0.30
In this study, we found that IL-32 level was increased by 58.2% in the serum samples from a cohort of 108 patients infected by influenza A virus comparing to that of 115 healthy individuals.
Positive_regulation (increased) of IL-32 associated with influenza virus infection
10) Confidence 0.35 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2288676 Disease Relevance 0.87 Pain Relevance 0.31
To define the role of COX-2 in the regulation of influenza A virus induced pro-inflammatory factor IL-32, poly(IC)+IFN-?
Positive_regulation (induced) of pro-inflammatory factor IL-32 in poly associated with inflammation and influenza virus infection
11) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2288676 Disease Relevance 1.09 Pain Relevance 0.21
Our results showed that influenza A virus infection or poly(IC) treatment activates COX-2 and IL-32 expression by a heretofore unrecognized mechanism, in which influenza A virus stimulates IL-32 expression through COX-2, and IL-32 feedback inhibits COX-2 expression.


Positive_regulation (stimulates) of IL-32 in poly associated with influenza virus infection and infection
12) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2288676 Disease Relevance 1.93 Pain Relevance 0.19
Our results can be summarized as follows: First, the expressions of major histocompatibility complex (MHC) class IF and II molecules, leukocyte immunoglobulin-like receptors, hepatitis A virus cellular receptor 2, and interleukin 32 were increased in bladder epithelial from IC and ulcerative IC area.
Positive_regulation (increased) of interleukin 32 in leukocyte
13) Confidence 0.10 Published 2010 Journal Int Urogynecol J Section Body Doc Link 20204322 Disease Relevance 0.12 Pain Relevance 0

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