INT166753

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.41
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cacna2d1)
Anatomy Link Frequency
neuronal 1
Cacna2d1 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 5 90.72 High High
Migraine 2 87.80 High High
Calcium channel 12 51.84 Quite High
ketamine 2 16.60 Low Low
anesthesia 2 15.28 Low Low
Glutamate 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Spinocerebellar Ataxia Type 2 3 99.72 Very High Very High Very High
Targeted Disruption 11 98.32 Very High Very High Very High
Disease 3 97.94 Very High Very High Very High
Channelopathies 2 95.98 Very High Very High Very High
Depression 5 90.72 High High
Ataxia 1 89.04 High High
Migraine With Aura 1 87.80 High High
Headache 1 87.68 High High
Epilepsy 1 86.96 High High
Neurological Disease 1 86.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Briefly, three sets of Cacna1fnob2 littermates of either sex (litter #1: n?
Gene_expression (littermates) of Cacna1fnob2
1) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2432030 Disease Relevance 0 Pain Relevance 0
Finally, while we did not systematically quantify the amplitudes of ERG oscillatory potentials, qualitatively they were depressed in Cacna1fnob2 as compared with those in Cacna1fwt mice.
Gene_expression (depressed) of Cacna1fnob2
2) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2432030 Disease Relevance 0.07 Pain Relevance 0.03
For each channelopathy, the review describes the disease phenotype as well as the functional consequences of the disease-causing mutations on recombinant human CaV2.1 channels and, in the case of FHM1 and SCA6, on neuronal CaV2.1 channels expressed at the endogenous physiological level in knockin mouse models.
Gene_expression (expressed) of CaV2.1 in neuronal associated with targeted disruption, spinocerebellar ataxia type 2, disease and channelopathies
3) Confidence 0.01 Published 2010 Journal Pflugers Arch. Section Abstract Doc Link 20204399 Disease Relevance 1.35 Pain Relevance 0.22

General Comments

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