INT166755

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Context Info
Confidence 0.73
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.16
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PHEX) protein modification process (PHEX) Golgi apparatus (PHEX)
endoplasmic reticulum (PHEX) plasma membrane (PHEX) cell-cell signaling (PHEX)
PHEX (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 23 90.12 High High
abdominal pain 3 77.12 Quite High
Central nervous system 1 70.28 Quite High
Enkephalin 4 63.52 Quite High
Action potential 7 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
medulla 3 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rickets 1 97.32 Very High Very High Very High
Myasthenia Gravis 168 92.16 High High
Osteoporosis 3 91.48 High High
Vomiting 9 77.60 Quite High
Abdominal Pain 3 77.12 Quite High
Diarrhoea 3 76.48 Quite High
Lymphatic System Cancer 2 70.88 Quite High
Lymphoproliferative Disease 1 67.84 Quite High
Anaemia 1 65.16 Quite High
Leukopenia 2 64.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For instance, while there is hallmark evidence for the importance of the endopeptidase Phex, whose inactivation in Hyp mice or human patients causes X-linked hypophosphatemic rickets, it is still largely unknown how Phex controls bone mineralization since a physiological substrate for its endopeptidase activity has not been identified yet.
Localization (importance) of Phex associated with rickets
1) Confidence 0.73 Published 2010 Journal Calcif. Tissue Int. Section Abstract Doc Link 20204609 Disease Relevance 0.19 Pain Relevance 0.12
PEX is generally reserved for short-term treatment to achieve rapid strength improvement in myasthenic exacerbations or crises, to prepare patients for thymectomy or another surgical procedure, to prevent steroid-related MG exacerbations in susceptible patients beginning corticosteroid treatment, and for rare patients refractory to all other treatments.
Localization (reserved) of PEX associated with corticosteroid and myasthenia gravis
2) Confidence 0.31 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2211463 Disease Relevance 0.97 Pain Relevance 0.16

General Comments

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