INT166764

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Context Info
Confidence 0.75
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.28
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mtor) mitochondrion (Mtor) Golgi apparatus (Mtor)
endoplasmic reticulum (Mtor) nucleus (Mtor) kinase activity (Mtor)
Anatomy Link Frequency
skin 2
nociceptors 1
Mtor (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nociceptor 164 99.76 Very High Very High Very High
Calcitonin gene-related peptide 36 98.68 Very High Very High Very High
Inflammatory response 4 93.40 High High
abdominal pain 1 90.96 High High
Inflammation 12 85.92 High High
Hyperalgesia 112 84.00 Quite High
Pain 32 79.08 Quite High
Sciatic nerve 20 76.48 Quite High
unmyelinated 16 58.36 Quite High
qutenza 156 45.28 Quite Low
Disease Link Frequency Relevance Heat
Splenomegaly 3 98.20 Very High Very High Very High
Pressure And Volume Under Development 3 96.84 Very High Very High Very High
INFLAMMATION 16 93.04 High High
Abdominal Pain 1 90.96 High High
Splenic Infarction 1 90.32 High High
Hyperalgesia 124 84.64 Quite High
Diabetes Mellitus 8 83.08 Quite High
Non-diabetic Peripheral Neuropathy 4 79.52 Quite High
Stress 4 68.36 Quite High
Hypoxia 4 67.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Relevance of the mTOR signaling pathway in the pathophysiology of splenomegaly in rats with chronic portal hypertension.
Localization (Relevance) of mTOR associated with pressure and volume under development and splenomegaly
1) Confidence 0.75 Published 2010 Journal J. Hepatol. Section Title Doc Link 20206401 Disease Relevance 0.57 Pain Relevance 0.09
We were also able to localize phosphorylated downstream targets of mTOR (Fig. 2A) co-existing with PGP, CGRP and N52 such as phospho-4E-BP1/2, phospho-S6K and phospho-S6 protein in skin tissue, (Fig. 2D-F and Fig. 3B).
Localization (localize) of mTOR in skin associated with calcitonin gene-related peptide
2) Confidence 0.64 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0 Pain Relevance 0.44
We were also able to localize phosphorylated downstream targets of mTOR (Fig. 2A) co-existing with PGP, CGRP and N52 such as phospho-4E-BP1/2, phospho-S6K and phospho-S6 protein in skin tissue, (Fig. 2D-F and Fig. 3B).
Localization (targets) of mTOR in skin associated with calcitonin gene-related peptide
3) Confidence 0.64 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0 Pain Relevance 0.43
Using western blotting and immunohistochemistry, we found that intraplantar injections of rapamycin reduced phosphorylation of downstream targets of mTOR, therefore suggesting that mTOR activity was inhibited by rapamycin.
Localization (targets) of mTOR
4) Confidence 0.64 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.09 Pain Relevance 0.08
One particular concern in the present series of experiments was the possible contribution of non-neuronal cells present in cutaneous tissues to maintaining the sensitivity of nociceptors through an mTOR mediated synthesis or release of trophic factors.
Localization (release) of mTOR in nociceptors associated with nociceptor
5) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.62 Pain Relevance 0.38

General Comments

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