INT166765

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Context Info
Confidence 0.70
First Reported 2006
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 21
Total Number 28
Disease Relevance 3.89
Pain Relevance 5.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PYCARD) signal transduction (PYCARD) intracellular (PYCARD)
cytoplasm (PYCARD)
Anatomy Link Frequency
striatum 2
brain 1
visual system 1
PYCARD (Homo sapiens)
Pain Link Frequency Relevance Heat
Transcranial magnetic stimulation 2275 100.00 Very High Very High Very High
Dopamine 85 100.00 Very High Very High Very High
poststroke pain 2 99.28 Very High Very High Very High
imagery 86 98.94 Very High Very High Very High
positron emission tomography 85 98.30 Very High Very High Very High
anesthesia 14 94.00 High High
depression 110 92.72 High High
MU agonist 5 83.88 Quite High
tolerance 1 83.32 Quite High
agonist 200 82.44 Quite High
Disease Link Frequency Relevance Heat
Cognitive Disorder 118 99.68 Very High Very High Very High
Convulsion 30 99.24 Very High Very High Very High
Stroke 37 99.08 Very High Very High Very High
Disease 98 99.02 Very High Very High Very High
Stress 50 99.00 Very High Very High Very High
Pain 91 98.80 Very High Very High Very High
Depression 148 95.60 Very High Very High Very High
Epilepsy 48 91.12 High High
Rigor 2 90.64 High High
Handedness 6 89.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A follow-up study in patients with early Parkinson's disease and unilateral motor symptoms revealed that the TMS-induced dopamine release in the striatum following ipsilateral M1 stimulation was lower and more spatially diffuse in the symptomatic hemisphere (Strafella et al., 2005).
Localization (release) of TMS-induced in striatum associated with dopamine, transcranial magnetic stimulation and disease
1) Confidence 0.70 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2950743 Disease Relevance 0.26 Pain Relevance 0.62
Such improvement in tactile detection ipsilateral to TMS could follow from interhemispheric rivalry, if one assumes that TMS disrupted cortical processing under the coil and thereby released the other hemisphere from inhibition.
Localization (released) of TMS associated with transcranial magnetic stimulation
2) Confidence 0.66 Published 2010 Journal Neuropsychologia Section Abstract Doc Link PMC2956832 Disease Relevance 0 Pain Relevance 0.31
For example, a recent diffusion tensor imaging study reported that connectivity patterns predicted TMS response in patients with post-stroke pain (Goto et al., 2008).


Localization (response) of TMS associated with pain, stroke, transcranial magnetic stimulation, poststroke pain and imagery
3) Confidence 0.65 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2950743 Disease Relevance 0.27 Pain Relevance 0.48
Prima facie, GCM and TMS chronometry are both measures of causality and information flow.
Localization (chronometry) of TMS associated with transcranial magnetic stimulation
4) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789405 Disease Relevance 0 Pain Relevance 0.29
Overall, it seems that both TMS over PPC and TMS over MFG had an effect on task-specific reaction times, as measured by RTdif scores.
Localization (over) of TMS associated with transcranial magnetic stimulation
5) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789405 Disease Relevance 0 Pain Relevance 0.19
From the last five participants, only a single run (700 volumes) was acquired, which still allowed robust localization of the TMS target regions.
Localization (localization) of TMS associated with transcranial magnetic stimulation
6) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789405 Disease Relevance 0 Pain Relevance 0.15
Investigational applications of TMS
Spec (Investigational) Localization (applications) of TMS associated with transcranial magnetic stimulation
7) Confidence 0.63 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671781 Disease Relevance 0.95 Pain Relevance 0.23
Another experimental application of TMS has been magnetic seizure therapy (MST), the use of rTMS at high stimulus frequency and intensity to deliberately induce a generalized seizure under anesthesia for the treatment of depression (Morales et al 2004).
Localization (application) of TMS associated with anesthesia, convulsion, depression and transcranial magnetic stimulation
8) Confidence 0.63 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671781 Disease Relevance 0.67 Pain Relevance 0.27
Analogously, TMS in studies of the motor (Dafotakis, Grefkes, Wang, Fink, & Nowak, 2008; Kobayashi, Hutchinson, Theoret, Schlaug, & Pascual-Leone, 2004) or visual system (Chambers, Stokes, Janko, & Mattingley, 2006; Dambeck et al., 2006; Hilgetag, Theoret, & Pascual-Leone, 2001) often cause either an ipsilateral enhancement or a contralateral decrement, but rarely both complementary patterns together, despite this being the simplest prediction from strict hemispheric rivalry.
Localization (cause) of TMS in visual system associated with transcranial magnetic stimulation
9) Confidence 0.61 Published 2010 Journal Neuropsychologia Section Body Doc Link PMC2956832 Disease Relevance 0 Pain Relevance 0.23
The findings that fMRI EC could successfully localize functionally relevant TMS target regions on the single subject level, and conversely, that TMS confirmed an fMRI EC identified functional network to be behaviorally relevant, have important methodological and theoretical implications.
Localization (localize) of TMS
10) Confidence 0.60 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2789405 Disease Relevance 0.07 Pain Relevance 0
According to our previous studies [11], [12], [66], the effect of rTMS on dopamine release is strictly limited to the ipsilateral hemisphere thus changes in extrastriatal DA BP of the stimulated hemisphere were tested against [11C]FLB 457 BP of the ipsilateral (non-stimulated) hemisphere of the other session (control) (Figure 4).
Localization (release) of rTMS associated with dopamine
11) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725302 Disease Relevance 0 Pain Relevance 0.18
In a recent rTMS/[11C]raclopride PET during set-shifting task, our group found a significant hemispheric asymmetry [56]. rTMS of the left DLPFC impaired executive task performance and dopamine release in the ipsilateral striatum while no effects were seen following right DLPFC stimulation.
Localization (release) of rTMS in striatum associated with dopamine and positron emission tomography
12) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725302 Disease Relevance 0.50 Pain Relevance 0.31
We did not test higher intensities for the Circ coil, as the subjects could easily identify whether they received a Standard/Reversed or Sham TMS.
Spec (whether) Localization (received) of TMS associated with transcranial magnetic stimulation
13) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2271126 Disease Relevance 0 Pain Relevance 0.73
There was a monotonic decrease in EMF for Standard (and Reversed) and Sham TMS as the distance increased (Fig. 2B-1).
Localization (decrease) of TMS associated with transcranial magnetic stimulation
14) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2271126 Disease Relevance 0 Pain Relevance 0.32
Four types of experiments were performed to validate the Standard, Reversed and Sham TMS delivered from the Fig8 and Circ coils.
Localization (delivered) of TMS associated with transcranial magnetic stimulation
15) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2271126 Disease Relevance 0 Pain Relevance 0.05
There was a monotonic decrease in EMF for both Standard (and Reversed) and Sham TMS as the stimulation intensity decreased (Fig. 2B-2).
Localization (decrease) of TMS associated with transcranial magnetic stimulation
16) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2271126 Disease Relevance 0 Pain Relevance 0.37
Here, we used controlled changes in the stimulation parameters (site, intensity, and angle of stimulation) and repeated longitudinal measurements (same day and one week apart) to evaluate the sensitivity and repeatability of TMS/hd-EEG potentials.


Localization (repeatability) of TMS associated with transcranial magnetic stimulation
17) Confidence 0.49 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2858649 Disease Relevance 0 Pain Relevance 0.25
In phase two, 201 individuals were randomly allocated by computer to either sham stimulation (n=99) or sTMS (n=102).
Localization (allocated) of sTMS
18) Confidence 0.34 Published 2010 Journal Lancet Neurol Section Body Doc Link 20206581 Disease Relevance 0.16 Pain Relevance 0
We are currently characterizing this ascorbate-AR peptide oxidation-reduction system in much more detail and preliminary data show that peptides derived from the first extracellular loops of B2AR and the histamine receptor are able to recycle Asc just as efficiently as glutathione on a mole-to-mole basis (unpublished data).
Localization (recycle) of Asc
19) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001466 Disease Relevance 0 Pain Relevance 0.03
In the unprocessed spectra on the left, six successive spectra over a period of more than one hour are superimposed as the AR +100 µM Asc, AR +30 µM Asc, and AR +10 µM Asc lines.
Localization (+100) of Asc
20) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001466 Disease Relevance 0 Pain Relevance 0

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