INT166766

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Context Info
Confidence 0.11
First Reported 2010
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.02
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Accn2)
Anatomy Link Frequency
brain 1
Accn2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ASIC 167 100.00 Very High Very High Very High
ischemia 162 95.08 Very High Very High Very High
tolerance 21 91.32 High High
Pain 4 77.48 Quite High
Root ganglion neuron 1 75.00 Quite High
IPN 1 74.32 Quite High
Pyramidal cell 15 56.00 Quite High
Action potential 2 42.24 Quite Low
Glutamate 3 26.00 Quite Low
Neuronal excitability 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Acidosis 31 97.96 Very High Very High Very High
Cv Unclassified Under Development 156 95.08 Very High Very High Very High
Death 27 91.60 High High
Apoptosis 15 90.80 High High
Injury 12 83.64 Quite High
Ganglion Cysts 1 75.00 Quite High
Inflammatory Pain 1 74.32 Quite High
Necrosis 6 51.20 Quite High
Brain Hemorrhage 9 50.00 Quite Low
Stroke 9 46.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the amplitude of a fast activating, rapidly inactivating ASIC1-like current was not affected by increasing the temperature but did result in an increased rate of desensitization that reduced the total current level.
Neg (not) Regulation (affected) of ASIC1-like
1) Confidence 0.11 Published 2010 Journal Brain Res. Section Abstract Doc Link 20206612 Disease Relevance 0.15 Pain Relevance 0.30
Preconditioning prior to the ischemic insult significantly up-regulated ASIC 2a mRNA compared to the ischemic insult alone (p < 0.01 at 24 h and p < 0.05 at 12 or 72 h, Figure 3).
Regulation (regulated) of ASIC associated with asic
2) Confidence 0.09 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.61 Pain Relevance 0.57
The up-regulation of ASIC 2a in the ischemic brain in response to prolonged acidosis may alter the composition of existing channels.
Regulation (regulation) of ASIC in brain associated with acidosis and asic
3) Confidence 0.09 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.57 Pain Relevance 0.72
Because the ASIC 2a channels seem to have a neuroprotective ability, we hypothesized that preconditioning, an experimental protocol known to induce endogenous neuroprotection, might up-regulate the ASIC 2a protein.
Spec (might) Regulation (regulate) of ASIC associated with asic
4) Confidence 0.09 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.70 Pain Relevance 0.57

General Comments

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