INT166790

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 1.46
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HRAS, PTGER1) Golgi apparatus (HRAS) GTPase activity (HRAS)
signal transducer activity (PTGER1) cytoplasm (HRAS) cytosol (HRAS)
Anatomy Link Frequency
fibroblasts 4
HRAS (Homo sapiens)
PTGER1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 3 99.84 Very High Very High Very High
Pain 6 99.56 Very High Very High Very High
rheumatoid arthritis 15 98.12 Very High Very High Very High
Inflammation 3 93.16 High High
COX2 6 80.64 Quite High
Disease Link Frequency Relevance Heat
Pain 6 99.56 Very High Very High Very High
Arthritis 6 99.36 Very High Very High Very High
Rheumatoid Arthritis 15 98.12 Very High Very High Very High
INFLAMMATION 3 93.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although HA has been shown to inhibit PGE(2) production in cytokine-stimulated synovial fibroblasts, it remains unclear how HA suppresses PGE(2) production in activated cells.
HA Negative_regulation (suppresses) of Gene_expression (production) of PGE in fibroblasts associated with cytokine
1) Confidence 0.01 Published 2010 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 20208419 Disease Relevance 0.64 Pain Relevance 0.37
Although HA has been shown to inhibit PGE(2) production in cytokine-stimulated synovial fibroblasts, it remains unclear how HA suppresses PGE(2) production in activated cells.
HA Negative_regulation (inhibit) of Gene_expression (production) of PGE in fibroblasts associated with cytokine
2) Confidence 0.01 Published 2010 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 20208419 Disease Relevance 0.66 Pain Relevance 0.38
These results indicate that HA suppresses the LPS-stimulated PGE(2) production via CD44 through down-regulation of NF-kappaB.
HA Negative_regulation (suppresses) of Gene_expression (production) of PGE
3) Confidence 0.01 Published 2010 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 20208419 Disease Relevance 0.15 Pain Relevance 0.20

General Comments

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