INT166792

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Context Info
Confidence 0.12
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.49
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD44, HRAS) cytosol (HRAS) signal transduction (HRAS)
Golgi apparatus (HRAS) cell adhesion (CD44) nucleus (HRAS)
Anatomy Link Frequency
macrophages 1
immune cells 1
CD44 (Homo sapiens)
HRAS (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 2 90.56 High High
rheumatoid arthritis 6 71.52 Quite High
Pain 3 62.40 Quite High
cytokine 18 59.92 Quite High
Inflammation 21 50.76 Quite High
headache 1 25.64 Quite Low
fibrosis 3 5.00 Very Low Very Low Very Low
Osteoarthritis 3 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 2 94.08 High High
Apoptosis 24 88.80 High High
Death 12 87.56 High High
Disorders Of The Lacrimal System 3 87.04 High High
Dry Eye 2 82.56 Quite High
Rheumatoid Arthritis 6 71.52 Quite High
Pain 3 57.16 Quite High
Arthritis 5 56.96 Quite High
INFLAMMATION 22 50.76 Quite High
Blindness 1 29.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fluorescence cytochemistry demonstrated that HA bound to CD44, the principal HA receptor, on U937 macrophages.
CD44 Binding (bound) of HA in macrophages
1) Confidence 0.12 Published 2010 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 20208419 Disease Relevance 0.47 Pain Relevance 0.37
HA interacts specifically with several cell surface receptors including CD44, which is considered the main HA cell-surface receptor [10].
CD44 Binding (interacts) of HA
2) Confidence 0.02 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 0.93 Pain Relevance 0
First, by interacting with transmembrane proteins, such as CD44 and other members of the heterogeneous group of proteins termed hyaladherins, HA initiates signaling pathways and contributes to the formation of the pericellular matrix that prevents direct contact between cells and protects them against attack from viruses, bacteria, and immune cells.
CD44 Binding (interacting) of HA in immune cells
3) Confidence 0.00 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175024 Disease Relevance 0.09 Pain Relevance 0

General Comments

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