INT166810

Context Info Confidence 0.10 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 5 Disease Relevance 2.16 Pain Relevance 0.08

mitochondrion (Casq1) Golgi apparatus (Casq1) molecular_function (Casq1) response to stress (Casq1) cytoplasm (Casq1)

Anatomy Link Frequency cardiomyocytes 1 Casq1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Pain 1 84.92 ischemia 8 5.00 tolerance 4 5.00 Glutamate 4 5.00 Inflammation 4 5.00 Morphine 4 5.00

Disease Link Frequency Relevance Heat Hypoxia 208 99.84 Muscle Disease 3 98.48 Muscle Weakness 1 86.36 Myalgia 1 84.92 Stress 24 69.04 Apoptosis 100 66.96 Myocardial Infarction 16 59.36 Shock 4 55.44 Death 16 48.72 Lymphatic System Cancer 4 43.12

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Considering that calsequestrin overexpression increases SR Ca2+ content by inhibition of RyRs,42 calsequestrin overexpression is also likely to contribute to intracellular Ca2+ overload.

Gene_expression (overexpression) of calsequestrin

1) Confidence 0.10 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.38 Pain Relevance 0

Considering that calsequestrin overexpression increases SR Ca2+ content by inhibition of RyRs,42 calsequestrin overexpression is also likely to contribute to intracellular Ca2+ overload.

Gene_expression (overexpression) of calsequestrin

2) Confidence 0.10 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.44 Pain Relevance 0

Our results showed increased expression of calsequestrin in hypoxia-reoxygenation condition (p < 0.05), but there was no significant change in response to exposure to thiopental.

Gene_expression (expression) of calsequestrin associated with hypoxia

3) Confidence 0.10 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.29 Pain Relevance 0

We found that these inclusions were positive for calsequestrin and for the calsequestrin-binding protein junctin, as well as for caveolin 3.

Gene_expression (positive) of calsequestrin

4) Confidence 0.08 Published 2010 Journal Neuromuscul. Disord. Section Abstract Doc Link 20211563 Disease Relevance 0.34 Pain Relevance 0.08

However, mRNA levels of Na+-Ca2+ exchanger (NCX) and calsequestrin increased in hypoxia-reoxygenated cardiomyocytes.

Gene_expression (exchanger) of calsequestrin in cardiomyocytes associated with hypoxia

5) Confidence 0.08 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.71 Pain Relevance 0

General Comments

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