INT166814

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Context Info
Confidence 0.46
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.95
Pain Relevance 3.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pag1) intracellular (Pag1)
Anatomy Link Frequency
neurons 1
midbrain 1
Pag1 (Mus musculus)
Pain Link Frequency Relevance Heat
Periaqueductal grey 110 100.00 Very High Very High Very High
Central grey 47 100.00 Very High Very High Very High
Raphe 8 100.00 Very High Very High Very High
qutenza 3 98.42 Very High Very High Very High
agonist 32 97.76 Very High Very High Very High
midbrain 20 97.72 Very High Very High Very High
Antinociceptive 4 96.46 Very High Very High Very High
gABA 17 95.48 Very High Very High Very High
GABAergic 54 92.24 High High
Sumatriptan 86 89.68 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 158 100.00 Very High Very High Very High
Diabetes Mellitus 10 99.84 Very High Very High Very High
Generalized Anxiety Disorder 2 90.48 High High
Sprains And Strains 15 87.20 High High
Hyperalgesia 4 75.00 Quite High
Pain 19 69.00 Quite High
Targeted Disruption 15 68.32 Quite High
Nociception 4 50.16 Quite High
Sleep Disorders 40 45.40 Quite Low
Headache 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is also consistent with prior studies which have reported that 5-HT1A levels within the PAG are relatively low compared to the adjacent dorsal raphe nucleus, and that 5-HT1A and 5-HT1B receptors are largely expressed within postsynaptic and presynaptic elements within the midbrain, respectively [43,44].
Transcription (expressed) of PAG in midbrain associated with periaqueductal grey, midbrain and raphe
1) Confidence 0.46 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.36 Pain Relevance 0.93
A previous report identified HCRT receptor mRNA in the vlPAG of rats [27], but in the present study immunohistochemistry determined that HCRT-2 receptor was present in eGFP/GABA neurons in the mouse vlPAG (Figure 7D).
Transcription (identified) of vlPAG in neurons associated with gaba
2) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.80 Pain Relevance 0.19
While previous experiments in rat using autoradiography and in situ hybridization have demonstrated the presence of 5-HT1A and 5-HT1B receptors in PAG, 5-HT1D receptor binding or mRNA was undetectable [21,22,25].
Transcription (undetectable) of PAG associated with periaqueductal grey
3) Confidence 0.18 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.29 Pain Relevance 0.50
PAG, but they used a much less sensitive retrograde tracer (i.e., the
Transcription (used) of PAG associated with central grey
4) Confidence 0.14 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0.45 Pain Relevance 0.50
In the present study antinociceptive effect of intra VL-PAG microinjections of CB1 and TRPV1 agonists [WIN55,212-2 (WIN) and capsaicin respectively] were compared in diabetic vs. non-diabetic rats, meanwhile mRNA expression of these receptors in PAG of diabetic and non-diabetic rats were evaluated by real time polymerase chain reaction (real time PCR) assay.
Transcription (expression) of PAG associated with qutenza, diabetes mellitus, agonist, central grey and antinociceptive
5) Confidence 0.03 Published 2010 Journal Brain Res. Section Abstract Doc Link 20211611 Disease Relevance 2.05 Pain Relevance 1.59

General Comments

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