INT166815

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Context Info
Confidence 0.10
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.80
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pag1) intracellular (Pag1)
Anatomy Link Frequency
GABAergic neurons 2
glutamatergic neurons 2
Pag1 (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 47 100.00 Very High Very High Very High
Central grey 19 100.00 Very High Very High Very High
gABA 6 100.00 Very High Very High Very High
antinociception 2 99.92 Very High Very High Very High
medulla 7 99.68 Very High Very High Very High
agonist 4 99.38 Very High Very High Very High
Antinociceptive 4 94.48 High High
midbrain 1 92.12 High High
Cannabinoid 1 88.00 High High
qutenza 3 86.16 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 23 100.00 Very High Very High Very High
Hyperalgesia 4 84.44 Quite High
Diabetes Mellitus 10 83.92 Quite High
Pain 1 81.68 Quite High
Generalized Anxiety Disorder 38 5.00 Very Low Very Low Very Low
Primary Sclerosing Cholangitis 19 5.00 Very Low Very Low Very Low
Sleep Disorders 8 5.00 Very Low Very Low Very Low
Camurati-engelmann Disease 2 5.00 Very Low Very Low Very Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Altogether, our results indicate that multiple populations of PS-on GABAergic neurons are distributed in the brainstem while only one population of PS-off GABAergic neurons localized in the vlPAG/dDpMe region exist.
Negative_regulation (population) of Localization (localized) of vlPAG in GABAergic neurons associated with medulla and gabaergic
1) Confidence 0.10 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2629845 Disease Relevance 0.07 Pain Relevance 0.47
CB1 receptor agonists also cause antinociception by decreasing Gamma Aminobutyric Acid (GABA) release in PAG and disinhibiting these glutamatergic neurons.
Negative_regulation (decreasing) of Localization (release) of PAG in glutamatergic neurons associated with antinociception, gaba, agonist and central grey
2) Confidence 0.03 Published 2010 Journal Brain Res. Section Abstract Doc Link 20211611 Disease Relevance 1.72 Pain Relevance 1.48

General Comments

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