INT166818

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.99
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IMPA1) mitochondrion (IMPA1) nucleolus (IMPA1)
nucleus (IMPA1) cytoplasm (IMPA1)
Anatomy Link Frequency
CSF 2
IMPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 28 100.00 Very High Very High Very High
Lasting pain 2 99.68 Very High Very High Very High
Pain 8 98.12 Very High Very High Very High
Acute pain 2 91.36 High High
Nicotine 16 29.12 Quite Low
agonist 18 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Acupuncture 3 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 10 99.68 Very High Very High Very High
Syndrome 1 98.76 Very High Very High Very High
Targeted Disruption 14 92.88 High High
Mitral Valve Insufficiency 9 82.04 Quite High
Myocardial Infarction 8 5.00 Very Low Very Low Very Low
Dilated Cardiomyopathy 6 5.00 Very Low Very Low Very Low
Stroke 5 5.00 Very Low Very Low Very Low
Fibrosis 4 5.00 Very Low Very Low Very Low
Coronary Heart Disease 4 5.00 Very Low Very Low Very Low
Left Ventricular Dysfunction 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The IMP can be calculated as
Positive_regulation (calculated) of Gene_expression (The) of IMP
1) Confidence 0.36 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1654186 Disease Relevance 0.08 Pain Relevance 0
The CSF levels of IMP, inosine, guanosine and uric acid were significantly increased in the chronic pain group and correlated with pain severity (P<0.05).
Positive_regulation (increased) of Gene_expression (levels) of IMP in CSF associated with pain and lasting pain
2) Confidence 0.27 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20211694 Disease Relevance 0.74 Pain Relevance 0.64
It is likely that Xyl-MRP and IMP produce their effects on the CT response to MSG by acting on the T1R3 part of the umami taste receptor (T1R1 + T1R3).
Positive_regulation (acting) of Gene_expression (produce) of IMP associated with glutamate
3) Confidence 0.04 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0.17 Pain Relevance 0.42

General Comments

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