INT166819

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Context Info
Confidence 0.65
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 3.85
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IMPA1) mitochondrion (IMPA1) nucleolus (IMPA1)
nucleus (IMPA1) cytoplasm (IMPA1)
Anatomy Link Frequency
brain 2
ventricle 1
muscle 1
tail 1
CSF 1
IMPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 57 98.72 Very High Very High Very High
Lasting pain 2 98.36 Very High Very High Very High
Pain 15 95.60 Very High Very High Very High
Action potential 1 90.20 High High
adenocard 6 87.04 High High
Neurotransmitter 1 87.04 High High
Acute pain 2 86.32 High High
iatrogenic 2 54.76 Quite High
anesthesia 12 38.36 Quite Low
Nicotine 32 32.52 Quite Low
Disease Link Frequency Relevance Heat
Endometriosis (extended) 2 98.92 Very High Very High Very High
Syndrome 3 98.76 Very High Very High Very High
Pain 17 98.36 Very High Very High Very High
Cryptococcal Meningitis 10 98.28 Very High Very High Very High
Infection 28 97.56 Very High Very High Very High
Targeted Disruption 28 96.28 Very High Very High Very High
Meningitis 8 91.76 High High
Coronary Heart Disease 12 90.00 High High
Heart Disease 6 83.96 Quite High
Chronic Disease 1 83.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The INO1 gene and inositol monophosphatase were found to be abundant in a SAGE library generated from RNAs isolated during brain infection, suggesting that the myo-inositol internal synthesis pathway is functional and that inositol could be important for the development of meningitis (34).
Gene_expression (found) of inositol monophosphatase in brain associated with meningitis and infection
1) Confidence 0.65 Published 2010 Journal mBio Section Body Doc Link PMC2912663 Disease Relevance 0.37 Pain Relevance 0.03
The INO1 gene and inositol monophosphatase were found to be abundant in a SAGE library generated from RNAs isolated during brain infection, suggesting that the myo-inositol internal synthesis pathway is functional and that inositol could be important for the development of meningitis (34).
Gene_expression (abundant) of inositol monophosphatase in brain associated with meningitis and infection
2) Confidence 0.65 Published 2010 Journal mBio Section Body Doc Link PMC2912663 Disease Relevance 0.37 Pain Relevance 0.03
However, the relationship between contractile alterations and IMP is less well delineated in the left ventricle with reduced LV function.
Gene_expression (alterations) of IMP in ventricle
3) Confidence 0.48 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1654186 Disease Relevance 0.49 Pain Relevance 0
As the LV ejection fraction was <40% (moderate LV dysfunction) in several animals, and the responses of IMP and ICT were uniform in most dogs, it might be reasonable to expect that inotropic stimulation with more severe LV dysfunction might produce similar responses in IMP and ICT.
Gene_expression (produce) of IMP
4) Confidence 0.48 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1654186 Disease Relevance 0.61 Pain Relevance 0
The IMP can be calculated as
Gene_expression (The) of IMP
5) Confidence 0.48 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1654186 Disease Relevance 0.08 Pain Relevance 0
The CSF levels of IMP, inosine, guanosine and uric acid were significantly increased in the chronic pain group and correlated with pain severity (P<0.05).
Gene_expression (levels) of IMP in CSF associated with pain and lasting pain
6) Confidence 0.42 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20211694 Disease Relevance 0.72 Pain Relevance 0.62
The finding of a lack of IMP accumulation or ATP decrease during exercise in the present study is consistent with other studies showing that no changes in muscle IMP, ATP or NH3 occur until PCr levels have significantly decreased to values below ?
Gene_expression (muscle) of IMP in muscle
7) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957441 Disease Relevance 0.14 Pain Relevance 0
This was done in two ways: first, r was calculated between the 'absolute' foot rotation angle in each condition and the corresponding PFM and IMP values obtained.
Gene_expression (values) of IMP in foot
8) Confidence 0.24 Published 2009 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2733135 Disease Relevance 0 Pain Relevance 0
IMP is not present in the cells under normal conditions and is converted to adenine, xanthine, and guanine nucleotides by the pathways shown in Figure 2.
Neg (not) Gene_expression (present) of IMP
9) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2831068 Disease Relevance 0 Pain Relevance 0.24
It is likely that Xyl-MRP and IMP produce their effects on the CT response to MSG by acting on the T1R3 part of the umami taste receptor (T1R1 + T1R3).
Gene_expression (produce) of IMP associated with glutamate
10) Confidence 0.06 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0.17 Pain Relevance 0.42
This suggests that IMP targets T1R3 to potentiate the CT response to MSG.
Gene_expression (targets) of IMP associated with glutamate
11) Confidence 0.05 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0.18 Pain Relevance 0.43
For the production of a clinical batch of IMP321, CHO DHFR- cells were transfected with a plasmid coding for the D1-D4 extra-cellular domains of human LAG-3 fused to the Fc tail of a human IgG1 [11].
Gene_expression (production) of IMP321 in tail
12) Confidence 0.02 Published 2007 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1852106 Disease Relevance 0.72 Pain Relevance 0

General Comments

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