INT166836

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.15
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein binding, bridging (ANXA1) cilium (ANXA1) protein complex (ANXA1)
lipid metabolic process (ANXA1) cytoplasm (ANXA1) signal transduction (ANXA1)
ANXA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 32 100.00 Very High Very High Very High
Potency 1 100.00 Very High Very High Very High
aspirin 5 92.44 High High
cINOD 7 89.72 High High
dexamethasone 1 80.16 Quite High
agonist 2 50.00 Quite Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 38 100.00 Very High Very High Very High
Apoptosis 6 97.68 Very High Very High Very High
Pancreatic Cancer 1 94.88 High High
Cancer 6 85.80 High High
Colon Cancer 1 64.40 Quite High
Alzheimer's Dementia 1 60.80 Quite High
Cytomegalovirus Infection 7 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 3 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Bacterial Respiratory Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, AnxA1 activation of ALX on the human PMN inhibited interaction with HUVEC monolayers as assessed with the flow chamber system.
Negative_regulation (inhibited) of Positive_regulation (activation) of AnxA1
1) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.25 Pain Relevance 0.10
The induction of ANXA1 by glucocorticoids was proportional to their anti-inflammatory potency, as was the suppression of NF-kappaB activity, which was accompanied by enhanced apoptosis and inhibition of cell growth mediated by changes in NF-kappaB-dependent cell signaling.
Negative_regulation (suppression) of Positive_regulation (induction) of ANXA1 associated with inflammation, apoptosis and potency
2) Confidence 0.37 Published 2010 Journal Cancer Res. Section Abstract Doc Link 20215502 Disease Relevance 0.90 Pain Relevance 0.48

General Comments

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