INT166838

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Context Info
Confidence 0.64
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 4.88
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein binding, bridging (ANXA1) cilium (ANXA1) protein complex (ANXA1)
lipid metabolic process (ANXA1) cytoplasm (ANXA1) signal transduction (ANXA1)
Anatomy Link Frequency
plasma 1
hypothalamus 1
colon 1
pituitary 1
adrenal glands 1
ANXA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 149 100.00 Very High Very High Very High
aspirin 13 99.96 Very High Very High Very High
cINOD 29 98.60 Very High Very High Very High
Potency 2 97.44 Very High Very High Very High
Inflammatory mediators 5 93.08 High High
Inflammatory response 5 87.72 High High
addiction 5 86.32 High High
dexamethasone 2 72.56 Quite High
agonist 10 50.00 Quite Low
chemokine 10 7.08 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 172 100.00 Very High Very High Very High
Breast Cancer 56 99.76 Very High Very High Very High
Pancreatic Cancer 2 98.84 Very High Very High Very High
Cytomegalovirus Infection 35 97.00 Very High Very High Very High
Apoptosis 27 93.88 High High
Cancer 59 93.28 High High
Immunotherapy Of Cancer 1 91.28 High High
Multiple Sclerosis 5 64.00 Quite High
Alzheimer's Dementia 5 60.80 Quite High
Colon Cancer 2 56.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, AnxA1 activation of ALX on the human PMN inhibited interaction with HUVEC monolayers as assessed with the flow chamber system.
Positive_regulation (activation) of AnxA1
1) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.25 Pain Relevance 0.09
We showed that glucocorticoids and chemopreventive modified nonsteroidal anti-inflammatory drugs, such as nitric oxide-donating aspirin (NO-ASA) and phospho-aspirin, induced ANXA1 in cultured human colon and pancreatic cancer cells.
Positive_regulation (induced) of ANXA1 in colon associated with aspirin, inflammation, pancreatic cancer and cinod
2) Confidence 0.60 Published 2010 Journal Cancer Res. Section Abstract Doc Link 20215502 Disease Relevance 0.78 Pain Relevance 0.47
The induction of ANXA1 by glucocorticoids was proportional to their anti-inflammatory potency, as was the suppression of NF-kappaB activity, which was accompanied by enhanced apoptosis and inhibition of cell growth mediated by changes in NF-kappaB-dependent cell signaling.
Positive_regulation (induction) of ANXA1 associated with inflammation, apoptosis and potency
3) Confidence 0.60 Published 2010 Journal Cancer Res. Section Abstract Doc Link 20215502 Disease Relevance 0.84 Pain Relevance 0.47
Although HEK293 cells lack receptors for AnxA1, these experiments were carried out using empty vector-transfected cells (CMV) treated with AnxA1 as controls, showing therefore that the effect of the protein is genuinely due to interaction with ALX, and not the result of non-specific interaction with other receptors present on the plasma membrane of HEK293 cells.
Positive_regulation (receptors) of AnxA1 in plasma associated with cytomegalovirus infection
4) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.23 Pain Relevance 0.03
Released by the concerted action of hormones acting on the hypothalamus, pituitary and adrenal glands, glucocorticoids augment the cellular levels of a downstream anti-inflammatory mediator, the 37-kDa protein Annexin 1 (AnxA1, formerly named lipocortin-1).
Positive_regulation (augment) of AnxA1 in pituitary associated with inflammation
5) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.64 Pain Relevance 0.36
Released by the concerted action of hormones acting on the hypothalamus, pituitary and adrenal glands, glucocorticoids augment the cellular levels of a downstream anti-inflammatory mediator, the 37-kDa protein Annexin 1 (AnxA1, formerly named lipocortin-1).
Positive_regulation (augment) of AnxA1 in adrenal glands associated with inflammation
6) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.64 Pain Relevance 0.36
Released by the concerted action of hormones acting on the hypothalamus, pituitary and adrenal glands, glucocorticoids augment the cellular levels of a downstream anti-inflammatory mediator, the 37-kDa protein Annexin 1 (AnxA1, formerly named lipocortin-1).
Positive_regulation (augment) of AnxA1 in hypothalamus associated with inflammation
7) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.64 Pain Relevance 0.36
WalBC cells exhibited expression of known markers of basal invasive human breast cancers as well as increased KRT17, KRT 14 and KRT 19, DSP, s100A4, NDRG-1, ANXA1, TK1 and AQP3 gene expression and decreased gene expression of TIMP3, VIM and TAGLN.
Positive_regulation (increased) of ANXA1 associated with breast cancer
8) Confidence 0.08 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2263075 Disease Relevance 0.87 Pain Relevance 0

General Comments

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