INT16687

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Context Info
Confidence 0.44
First Reported 1986
Last Reported 2008
Negated 0
Speculated 3
Reported most in Abstract
Documents 6
Total Number 9
Disease Relevance 0.23
Pain Relevance 6.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cndp2) peptidase activity (Cndp2) cytoplasm (Cndp2)
Anatomy Link Frequency
tail 1
vas deferens 1
Cndp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 32 100.00 Very High Very High Very High
narcan 9 100.00 Very High Very High Very High
Analgesic 7 100.00 Very High Very High Very High
withdrawal 3 99.72 Very High Very High Very High
Antinociceptive 7 99.24 Very High Very High Very High
agonist 2 98.88 Very High Very High Very High
Potency 8 98.80 Very High Very High Very High
tail-flick 1 98.48 Very High Very High Very High
antinociception 10 98.44 Very High Very High Very High
opioid receptor 4 98.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 3 85.20 High High
Nociception 2 75.00 Quite High
Pain 1 65.40 Quite High
Protozoal Infection 1 5.00 Very Low Very Low Very Low
Anaemia 1 5.00 Very Low Very Low Very Low
Helminth Infection 1 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low
Rickets 1 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The tyrosine in the VNAFY motif of human neprilysin is part of a hydrogen bonding network, which is conserved in other M13 peptidases [46,47].
Regulation (conserved) of peptidase
1) Confidence 0.44 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2259306 Disease Relevance 0.09 Pain Relevance 0.04
The pretreatment with the delta opioid antagonists ICI 154,129 (20 micrograms, i.c.v.) or ICI 174,864 (2-4 micrograms, i.c.v.) strongly decreased the effects of all the peptidase inhibitors we tested.
Regulation (effects) of peptidase associated with antagonist and opioid
2) Confidence 0.39 Published 1990 Journal Neuropeptides Section Abstract Doc Link 1981928 Disease Relevance 0 Pain Relevance 0.69
These tests could be classified into two groups: (i) those tests in which the two peptidase inhibitors display naloxone-sensitive antinociceptive activity, particularly when administered together, and in which naloxone displays pronociceptive activity (vocalisation, hot-plate jump, writhing), (ii) those tests in which the two peptidase inhibitors and naloxone are ineffective (tail withdrawal, hot-plate licking, tail-flick).
Regulation (ineffective) of peptidase in tail associated with tail-flick, narcan, withdrawal and antinociceptive
3) Confidence 0.38 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3519246 Disease Relevance 0.07 Pain Relevance 1.16
Several peptides of diverse structure, reported to possess high affinity and selectivity for the delta opioid receptor, were studied using the mouse isolated vas deferens preparation to determine the effect of peptidase inhibition on their apparent potency.
Spec (determine) Regulation (effect) of peptidase in vas deferens associated with opioid receptor and potency
4) Confidence 0.27 Published 1991 Journal Life Sci. Section Abstract Doc Link 1847736 Disease Relevance 0 Pain Relevance 0.85
Influence of peptidase inhibitors on the apparent agonist potency of delta selective opioid peptides in vitro.
Regulation (Influence) of peptidase associated with analgesic, agonist, opioid and potency
5) Confidence 0.27 Published 1991 Journal Life Sci. Section Title Doc Link 1847736 Disease Relevance 0 Pain Relevance 1.13
In the present study, we have examined the effect of peptidase inhibitors on the behavioral response elicited by intrathecal injection of nociceptin in mice.
Spec (examined) Regulation (effect) of peptidase associated with orphanin and intrathecal
6) Confidence 0.13 Published 2002 Journal Biochem. Pharmacol. Section Abstract Doc Link 12234609 Disease Relevance 0.07 Pain Relevance 0.88
These results indicate that dipeptidyl peptidase IV may be an important peptidase responsible for terminating endomorphin-2-induced antinociception at the supraspinal level in mice.
Regulation (responsible) of peptidase associated with antinociception
7) Confidence 0.11 Published 2003 Journal Biochem. Pharmacol. Section Abstract Doc Link 12906930 Disease Relevance 0 Pain Relevance 0.33
The effects of peptidase inhibitors on the antinociceptive induced by intrathecally (i.t.) administered by dynorphin A and dynorphin B in the mouse formalin test were examined.
Spec (examined) Regulation (effects) of peptidase associated with dynorphin and antinociceptive
8) Confidence 0.09 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8957219 Disease Relevance 0 Pain Relevance 0.47
These results indicate that dipeptidyl peptidase IV may be an important peptidase responsible for terminating endomorphin-2-induced antinociception at the supraspinal level in mice.
Regulation (responsible) of peptidase associated with antinociception
9) Confidence 0.08 Published 2004 Journal Yakugaku Zasshi Section Abstract Doc Link 15297724 Disease Relevance 0 Pain Relevance 0.56

General Comments

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