INT166879

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Context Info
Confidence 0.71
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 3.62
Pain Relevance 2.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ccr5) signal transduction (Ccr5) plasma membrane (Ccr5)
cell-cell signaling (Ccr5) cytoplasm (Ccr5) signal transducer activity (Ccr5)
Anatomy Link Frequency
macrophages 1
Schwann cells 1
Ccr5 (Mus musculus)
Pain Link Frequency Relevance Heat
Sciatic nerve 10 100.00 Very High Very High Very High
antagonist 57 99.96 Very High Very High Very High
cytokine 3 99.52 Very High Very High Very High
chemokine 34 99.34 Very High Very High Very High
Thermal hyperalgesia 6 97.80 Very High Very High Very High
Brush evoked pain 6 96.80 Very High Very High Very High
opiate 1 96.50 Very High Very High Very High
Inflammation 16 84.16 Quite High
Neuropathic pain 10 78.00 Quite High
Peripheral nerve injury 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 6 97.80 Very High Very High Very High
Neuropathic Pain 16 96.80 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 178 92.08 High High
Disease 12 91.28 High High
INFLAMMATION 11 84.16 Quite High
Nervous System Injury 2 75.00 Quite High
Infection 18 57.68 Quite High
Syndrome 3 50.88 Quite High
Immunodeficiency 6 50.52 Quite High
Severe Combined Immunodeficiency 3 18.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Viruses that use the CCR5 or the CXCR4 coreceptors alone are called R5 or X4 viruses respectively, while those that can use both are referred to as R5X4 viruses.
Localization (use) of CCR5
1) Confidence 0.71 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.57 Pain Relevance 0.05
However, results from most resistance studies, thus far, suggest that this switch to CXCR4 usage is in fact not observed frequently and instead viruses usually acquire resistance to these drugs by using a drug-bound conformation of the CCR5 coreceptor.
Localization (conformation) of CCR5
2) Confidence 0.71 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.21 Pain Relevance 0.05
Another key issue in the optimal administration of CCR5 antagonists, such as maraviroc, is which patient should receive these drugs: treatment-experienced or treatment-naïve patients?
Localization (administration) of CCR5 associated with antagonist
3) Confidence 0.71 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.20 Pain Relevance 0.05
MIP-1alpha receptors (CCR1 and CCR5) mRNA and their proteins were also up-regulated in the SCN after PSL, and were localized on macrophages and Schwann cells.
Localization (localized) of CCR5 in macrophages associated with sciatic nerve
4) Confidence 0.70 Published 2010 Journal Pain Section Abstract Doc Link 20223588 Disease Relevance 1.00 Pain Relevance 1.13
MIP-1alpha receptors (CCR1 and CCR5) mRNA and their proteins were also up-regulated in the SCN after PSL, and were localized on macrophages and Schwann cells.
Localization (localized) of CCR5 in Schwann cells associated with sciatic nerve
5) Confidence 0.24 Published 2010 Journal Pain Section Abstract Doc Link 20223588 Disease Relevance 1.00 Pain Relevance 1.13
Tat and opiates have interactive effects on astroglial chemokine secretion, but this interaction did not occur in progenitors. gp120 did not affect chemokine/cytokine release, although both CCR5 and CXCR4, which serve as gp120 co-receptors, were detected in progenitors.
Localization (serve) of CCR5 associated with chemokine, opiate and cytokine
6) Confidence 0.19 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20403075 Disease Relevance 0.65 Pain Relevance 0.58

General Comments

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