INT166881

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 31
Total Number 31
Disease Relevance 18.14
Pain Relevance 7.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ccr1) plasma membrane (Ccr1) cell-cell signaling (Ccr1)
signal transducer activity (Ccr1)
Anatomy Link Frequency
myotubes 4
diaphragm 2
brain 2
muscle cells 2
macrophages 1
Ccr1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 853 100.00 Very High Very High Very High
cytokine 400 100.00 Very High Very High Very High
Sciatic nerve 11 99.68 Very High Very High Very High
Inflammation 448 98.72 Very High Very High Very High
Demyelination 12 98.20 Very High Very High Very High
Thermal hyperalgesia 6 98.16 Very High Very High Very High
antagonist 18 97.84 Very High Very High Very High
Inflammatory response 75 97.72 Very High Very High Very High
Brush evoked pain 6 97.16 Very High Very High Very High
Inflammatory stimuli 47 82.64 Quite High
Disease Link Frequency Relevance Heat
Infection 478 99.98 Very High Very High Very High
Hypercalcemia 59 99.96 Very High Very High Very High
Disease Progression 10 99.92 Very High Very High Very High
Disease 212 99.72 Very High Very High Very High
Endotoxemia 135 99.68 Very High Very High Very High
Sepsis 390 99.46 Very High Very High Very High
INFLAMMATION 555 98.72 Very High Very High Very High
Pseudomonas Infection 60 98.24 Very High Very High Very High
Demyelinating Disease 80 98.20 Very High Very High Very High
Hyperalgesia 6 98.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, both CCR1 and CCR5 were significantly upregulated in the TA muscle at 6 hours after LPS administration.
Positive_regulation (upregulated) of CCR1 in muscle
1) Confidence 0.69 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.21 Pain Relevance 0.03
Both sepsis models triggered a marked upregulation of RANTES and MIP-1?
Positive_regulation (upregulation) of RANTES associated with sepsis
2) Confidence 0.69 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2676322 Disease Relevance 0.82 Pain Relevance 0.17
In this regard, we have recently reported a marked upregulation of CCR1 and two of its major ligands, RANTES (CCL5) and MIP-1?
Positive_regulation (upregulation) of RANTES
3) Confidence 0.69 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.91 Pain Relevance 0.39
In this regard, we have recently reported a marked upregulation of CCR1 and two of its major ligands, RANTES (CCL5) and MIP-1?
Positive_regulation (upregulation) of CCR1
4) Confidence 0.69 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.84 Pain Relevance 0.39
It has been observed that C-C chemokines, such as MIP-1-alpha and RANTES, are significantly upregulated in brains of Trypanosoma brucei brucei infected rats [34].
Positive_regulation (upregulated) of MIP-1-alpha in brains associated with chemokine
5) Confidence 0.58 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.39 Pain Relevance 0.23
TEPM expressed elevated levels of mRNA for Cxcr4, Ccr1, Ccrl2, whilst BMM expressed higher levels of Ccr2, Cx3cr1 and Cxcr3.
Positive_regulation (elevated) of Ccr1
6) Confidence 0.54 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.31 Pain Relevance 0.18
MIP-1alpha receptors (CCR1 and CCR5) mRNA and their proteins were also up-regulated in the SCN after PSL, and were localized on macrophages and Schwann cells.
Positive_regulation (up-regulated) of CCR1 in macrophages associated with sciatic nerve
7) Confidence 0.46 Published 2010 Journal Pain Section Abstract Doc Link 20223588 Disease Relevance 0.99 Pain Relevance 1.09
However, only CCR1 showed upregulation in the diaphragm during sepsis, and this was observed at the 24-hour time point.
Positive_regulation (upregulation) of CCR1 in diaphragm associated with sepsis
8) Confidence 0.46 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.22 Pain Relevance 0.03
We have previously reported that primary diaphragmatic myotubes also demonstrate significant upregulation of CCR1 but not CCR5 during proinflammatory cytokine stimulation in vitro [16], which is in keeping with the greater upregulation of CCR1 during endotoxemia shown in the present study.
Positive_regulation (upregulation) of CCR1 in myotubes associated with endotoxemia and cytokine
9) Confidence 0.46 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.54 Pain Relevance 0.26
We have previously reported that primary diaphragmatic myotubes also demonstrate significant upregulation of CCR1 but not CCR5 during proinflammatory cytokine stimulation in vitro [16], which is in keeping with the greater upregulation of CCR1 during endotoxemia shown in the present study.
Positive_regulation (upregulation) of CCR1 in myotubes associated with endotoxemia and cytokine
10) Confidence 0.46 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.61 Pain Relevance 0.26
Here we sought to study the local expression and
                             molecular regulation of the chemokines, regulated upon activation
                             normal T cell expressed and secreted (RANTES) and macrophage
                             inflammatory protein (MIP)-1?
Positive_regulation (activation) of RANTES in T cell associated with chemokine and inflammation
11) Confidence 0.43 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2676322 Disease Relevance 0.80 Pain Relevance 0.23
Inhibition of
                             the NF-kB pathway using pharmacologic or dominant negative genetic
                             approaches blocked the LPS-induced RANTES upregulation, while free
                             radical scavengers had no effect. 
Positive_regulation (upregulation) of RANTES
12) Confidence 0.43 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2676322 Disease Relevance 0.54 Pain Relevance 0.16
B pathway were effective in suppressing LPS-induced upregulation of RANTES.
Positive_regulation (upregulation) of RANTES
13) Confidence 0.43 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.19 Pain Relevance 0.04
In vitro, stimulation of diaphragmatic
                             muscle cells with LPS also led to RANTES upregulation. 
Positive_regulation (upregulation) of RANTES in muscle cells
14) Confidence 0.43 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2676322 Disease Relevance 0.78 Pain Relevance 0.19
However, exposure of the cultured diaphragmatic myotubes to LPS markedly upregulated RANTES (see Figure 4(a)) but had no measurable effect on MIP-1?
Positive_regulation (upregulated) of RANTES in myotubes
15) Confidence 0.40 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.14 Pain Relevance 0.13
and RANTES within limb muscles under the same conditions (data not shown), and the levels of chemokine upregulation in the diaphragm at both time points after Pseudomonas infection were greater (relative to control) than following acute LPS administration.

3.3.

Positive_regulation (upregulation) of RANTES in diaphragm associated with chemokine and pseudomonas infection
16) Confidence 0.40 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.46 Pain Relevance 0.23
B pathway in LPS-induced RANTES upregulation by muscle cells.
Positive_regulation (upregulation) of RANTES in muscle cells
17) Confidence 0.40 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.27 Pain Relevance 0.13
To further explore the mechanism of RANTES upregulation by muscle cells after LPS stimulation, we transfected C2C12 cells (skeletal muscle cell line) with a plasmid containing the RANTES promoter linked to a luciferase reporter gene, and the transfected cells were then once again stimulated with LPS at the myotube stage.
Positive_regulation (upregulation) of RANTES in myotube
18) Confidence 0.40 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.13 Pain Relevance 0.10
In conclusion, P. yoelii 17XL infection upregulates RANTES and its corresponding receptors, CCR1, CCR3 and CCR5, in mouse brain, and that ultrastructural changes in the microvascular endothelial layer occurred in the cerebellum of infected mice.
Positive_regulation (upregulates) of CCR1 in brain associated with infection
19) Confidence 0.39 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.50 Pain Relevance 0.14
RANTES (p < 0.002), CCR1 (p < 0.036), CCR3 (p < 0.033), and CCR5 (p < 0.026) mRNA were significantly upregulated at peak parasitaemia and remained high thereafter in the experimental mouse model.
Positive_regulation (upregulated) of CCR1
20) Confidence 0.39 Published 2005 Journal Malar J Section Abstract Doc Link PMC1343570 Disease Relevance 0.56 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox