INT166885

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.60
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pparg) signal transduction (Pparg) nucleus (Pparg)
enzyme binding (Pparg) DNA binding (Pparg) cytoplasm (Pparg)
Pparg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 3 96.96 Very High Very High Very High
antagonist 4 80.68 Quite High
cytokine 1 80.68 Quite High
COX2 1 25.00 Low Low
tolerance 9 20.96 Low Low
agonist 7 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 36 99.56 Very High Very High Very High
Stress 11 99.14 Very High Very High Very High
Hyperinsulinism 10 96.88 Very High Very High Very High
Shock 1 84.16 Quite High
Coronary Artery Disease 39 84.08 Quite High
Insulin Resistance 24 81.48 Quite High
Hypertension 6 80.56 Quite High
Sprains And Strains 1 75.00 Quite High
Diabetes Mellitus 94 74.92 Quite High
Pathologic Constriction 3 69.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reducing FSH during the neonatal period, or the ability to respond to FSH, did not decrease expression of mRNA for PPARgamma.
Neg (not) Negative_regulation (decrease) of Gene_expression (expression) of PPARgamma
1) Confidence 0.41 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2795759 Disease Relevance 0 Pain Relevance 0.04
Genetic variation of PPARG 54,347 C > T (designated “PPARG 161 C > T” in the publication), PPARG Pro12Ala, and PPARG 25,506 C > T as well as the association with baseline
Negative_regulation (Genetic) of Gene_expression (variation) of PPARG
2) Confidence 0.33 Published 2008 Journal PPAR Research Section Body Doc Link PMC2288645 Disease Relevance 0.40 Pain Relevance 0
compared to PPARG Pro12 homozygotes, only the obese subgroup demonstrated
Negative_regulation (compared) of Gene_expression (homozygotes) of PPARG associated with obesity
3) Confidence 0.33 Published 2008 Journal PPAR Research Section Body Doc Link PMC2288645 Disease Relevance 0.91 Pain Relevance 0
Genetic variation of PPARG 54,347 C > T (designated “PPARG 161 C > T” in the publication), PPARG Pro12Ala, and PPARG 25,506 C > T as well as the association with baseline
Negative_regulation (Genetic) of Gene_expression (variation) of PPARG
4) Confidence 0.29 Published 2008 Journal PPAR Research Section Body Doc Link PMC2288645 Disease Relevance 0.40 Pain Relevance 0
The exposure to WRS was accompanied by an increase in gastric mucosal expression of IL-1beta, ghrelin, PPARgamma, HSP70 and COX-2.
Negative_regulation (mucosal) of Gene_expression (expression) of PPARgamma associated with stress
5) Confidence 0.20 Published 2009 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 20224150 Disease Relevance 0.89 Pain Relevance 0.21

General Comments

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