INT166886

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 8
Disease Relevance 4.11
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrl) extracellular region (Ghrl) cytoplasm (Ghrl)
Anatomy Link Frequency
plasma 2
brain 2
Ghrl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 12 99.80 Very High Very High Very High
qutenza 3 96.96 Very High Very High Very High
depression 15 87.24 High High
antagonist 116 84.32 Quite High
agonist 102 83.68 Quite High
cytokine 28 80.68 Quite High
Somatostatin 42 74.76 Quite High
addiction 12 54.48 Quite High
tolerance 24 51.04 Quite High
Potency 6 49.04 Quite Low
Disease Link Frequency Relevance Heat
Repression 36 100.00 Very High Very High Very High
Hyperphagia 6 100.00 Very High Very High Very High
Targeted Disruption 102 99.98 Very High Very High Very High
Polycystic Ovary Syndrome 18 99.74 Very High Very High Very High
Stress 97 99.14 Very High Very High Very High
Insulin Resistance 30 99.00 Very High Very High Very High
Obesity 91 98.50 Very High Very High Very High
Hypoglycemia 24 98.28 Very High Very High Very High
Syndrome 18 98.14 Very High Very High Very High
Anxiety Disorder 23 94.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The exposure to WRS was accompanied by an increase in gastric mucosal expression of IL-1beta, ghrelin, PPARgamma, HSP70 and COX-2.
Negative_regulation (mucosal) of Gene_expression (expression) of ghrelin associated with stress
1) Confidence 0.41 Published 2009 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 20224150 Disease Relevance 0.89 Pain Relevance 0.21
It has been proposed that this elevated ghrelin helps animals cope with stress by generating antidepressant-like behavioral adaptations, although another study suggests that decreasing CNS ghrelin expression has antidepressant-like effects.
Negative_regulation (decreasing) of Gene_expression (expression) of ghrelin associated with stress and antidepressant
2) Confidence 0.34 Published 2010 Journal International Journal of Peptides Section Abstract Doc Link PMC2915752 Disease Relevance 0.61 Pain Relevance 0.10
An exception is the genetic Prader-Willi syndrome marked by obesity, mild insulin resistance, and unexplained hyperghrelinemia with increased numbers of gastric ghrelin-expressing cells [449–451].
Negative_regulation (numbers) of Gene_expression (expressing) of ghrelin associated with syndrome, obesity and insulin resistance
3) Confidence 0.23 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.80 Pain Relevance 0.09
These factors depress brain ghrelin expression, while promoting gastric ghrelin secretion and amplifying CNS responses to ghrelin [9, 418, 419].
Negative_regulation (depress) of Gene_expression (expression) of ghrelin in brain
4) Confidence 0.23 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.44 Pain Relevance 0.08
The antiandrogen, flutamide, increased ghrelin levels in patients with PCOS, suggesting suppression of ghrelin production via the androgen receptor in this hyperandrogenemic syndrome [152].

2.5.

Negative_regulation (suppression) of Gene_expression (production) of ghrelin associated with syndrome and polycystic ovary syndrome
5) Confidence 0.23 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.55 Pain Relevance 0.07
In this regard, oral octanoate increases, but oral dodecanoate decreases, plasma octanoylated ghrelin levels [134].
Negative_regulation (octanoylated) of Gene_expression (levels) of ghrelin in plasma
6) Confidence 0.23 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.06 Pain Relevance 0
Transgenic overexpression of CNS and gastric ghrelin causes hyperphagia, increases energy expenditure, and decreases sensitivity to insulin and leptin in mice [170].
Negative_regulation (decreases) of Gene_expression (overexpression) of ghrelin associated with hyperphagia and targeted disruption
7) Confidence 0.20 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.48 Pain Relevance 0.03
In humans, exogenous desacyl-ghrelin does not restrict ghrelin-induced GH secretion but disinhibits ghrelin's repression of insulin secretion [210, 221, 226].
Negative_regulation (disinhibits) of Gene_expression (repression) of ghrelin associated with repression
8) Confidence 0.20 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.27 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox