INT166889

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Context Info
Confidence 0.70
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 6.43
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transporter activity (AQP1) plasma membrane (AQP1) nucleus (AQP1)
transmembrane transport (AQP1) cytoplasm (AQP1)
Anatomy Link Frequency
plasma 6
cerebral cortex 4
astrocytes 3
pancreas 2
capillary 1
AQP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cerebral cortex 9 100.00 Very High Very High Very High
Chronic pancreatitis 8 96.52 Very High Very High Very High
Inflammation 22 94.32 High High
fibrosis 4 71.84 Quite High
Hippocampus 5 63.04 Quite High
potassium channel 13 42.92 Quite Low
Substantia nigra 8 37.20 Quite Low
Dopamine 32 21.28 Low Low
Spinal cord 46 19.56 Low Low
Multiple sclerosis 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 380 99.46 Very High Very High Very High
Lewy Body Disease 12 99.40 Very High Very High Very High
Alzheimer's Dementia 27 99.20 Very High Very High Very High
Creutzfeldt Jakob Disease 40 99.08 Very High Very High Very High
Pancreatitis 12 97.08 Very High Very High Very High
Congenital Anomalies 8 96.44 Very High Very High Very High
Stress 23 95.28 Very High Very High Very High
INFLAMMATION 23 94.32 High High
Prion Diseases 24 87.52 High High
Shock 2 84.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AQP1 expression was significantly increased in plasma membranes of pancreatic ducts in AIP.
Positive_regulation (increased) of Gene_expression (expression) of AQP1 in plasma
1) Confidence 0.70 Published 2009 Journal J. Med. Invest. Section Abstract Doc Link 20224214 Disease Relevance 0.22 Pain Relevance 0.18
Upregulation of AQP1 expression seen in pancreatic ducts of patient with AIP may be caused by the reduced fluid secretion from the pancreas as compensation.
Positive_regulation (Upregulation) of Gene_expression (expression) of AQP1 in pancreas
2) Confidence 0.70 Published 2009 Journal J. Med. Invest. Section Abstract Doc Link 20224214 Disease Relevance 0.22 Pain Relevance 0.18
Aquaporin 1 water channel is overexpressed in the plasma membranes of pancreatic ducts in patients with autoimmune pancreatitis.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of water channel in plasma associated with pancreatitis
3) Confidence 0.61 Published 2009 Journal J. Med. Invest. Section Title Doc Link 20224214 Disease Relevance 0.28 Pain Relevance 0.18
Aquaporin 1 water channel is overexpressed in the plasma membranes of pancreatic ducts in patients with autoimmune pancreatitis.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Aquaporin 1 in plasma associated with pancreatitis
4) Confidence 0.44 Published 2009 Journal J. Med. Invest. Section Title Doc Link 20224214 Disease Relevance 0.28 Pain Relevance 0.18
The present findings showing increased AQP1 expression in selected astrocytes may represent a link between well-known arteriolar and capillary abnormalities [23, 46] and specific responses to water transport in perivascular processes of astrocytes in AD.
Positive_regulation (increased) of in astrocytes Gene_expression (expression) of AQP1 in capillary associated with congenital anomalies and disease
5) Confidence 0.41 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.55 Pain Relevance 0.04
Significant increased expression levels of AQP1 and AQP4 were seen in CJD, but not in advanced AD and DLB cases.
Positive_regulation (increased) of Gene_expression (levels) of AQP1 associated with creutzfeldt jakob disease, lewy body disease and disease
6) Confidence 0.41 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.55 Pain Relevance 0.05
The subgroup of aquaporins is composed of AQP0, AQP1, AQP2, AQP4, AQP5, AQP6 and AQP8 and is considered to be mainly permeable to water with a high flow rate.
Positive_regulation (subgroup) of Gene_expression (composed) of AQP1
7) Confidence 0.33 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0 Pain Relevance 0
To evaluate the hypothesis described above, a recent study using combined Western blotting and immunohistochemistry in a selected number of sporadic and familial AD showed that the levels of AQP1 expression are significantly elevated in the frontal cerebral cortex of AD patients.
Positive_regulation (elevated) of Gene_expression (expression) of AQP1 in cerebral cortex associated with disease and cerebral cortex
8) Confidence 0.29 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.62 Pain Relevance 0.08
However, treatment with hydrogen peroxide did not affect the levels of AQP1 protein expression in human astrocytes culture, suggesting that these stimuli do not directly up-regulate AQP1 expression in astrocytes.
Neg (not) Positive_regulation (regulate) of Gene_expression (expression) of AQP1 in astrocytes
9) Confidence 0.27 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.88 Pain Relevance 0
Aquaporin 1 (AQP1) expression in the cerebral cortex was shown to have been increased at early stages of Alzheimer disease [36].
Positive_regulation (increased) of Gene_expression (expression) of AQP1 in cerebral cortex associated with alzheimer's dementia and cerebral cortex
10) Confidence 0.26 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2848146 Disease Relevance 1.83 Pain Relevance 0.10

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