INT166959

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Context Info
Confidence 0.46
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.23
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (SP1) nucleus (SP1) intracellular (SP1)
DNA binding (SP1) transcription factor binding (SP1) cytoplasm (SP1)
Anatomy Link Frequency
colon 2
proximal 2
SP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Cannabinoid receptor 2 80.72 Quite High
cINOD 7 75.00 Quite High
cytokine 4 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 10 98.60 Very High Very High Very High
Immunotherapy Of Cancer 2 98.40 Very High Very High Very High
Death 4 97.76 Very High Very High Very High
Adhesions 5 94.88 High High
Cancer 6 92.96 High High
Familial Adenomatous Polyposis 4 88.40 High High
Apoptosis 6 86.56 High High
INFLAMMATION 3 63.08 Quite High
Focal Cartilage Defect 3 27.68 Quite Low
Osteoarthritis 4 13.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that induction of NAG-1 via Sp1 activation is a promising therapeutic approach in cancer treatment, and that a novel compound like LYR-8 could be a potent chemotherapeutic agent for colon cancers including p53-mutated cancer.
Positive_regulation (induction) of Positive_regulation (activation) of Sp1 in colon associated with cancer, colon cancer and immunotherapy of cancer
1) Confidence 0.46 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20230799 Disease Relevance 1.06 Pain Relevance 0.10
The induction of NAG-1 promoter activity by LYR-8 was strongly correlated with increased Sp1 activation as noted in various luc-promoter activities.
Positive_regulation (increased) of Positive_regulation (activation) of Sp1
2) Confidence 0.46 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20230799 Disease Relevance 0.89 Pain Relevance 0.24
At the level of transcriptional regulation, changes in the levels of cellular binding of the transcription factors Sp-1 and AP-2 to their cognate response DNA sequences contained within the proximal promoter region of the gene of a cartilage matrix component, aggrecan, are indeed the targets of TGF-?
Positive_regulation (cellular) of Positive_regulation (factors) of Sp-1 in proximal
3) Confidence 0.06 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.27 Pain Relevance 0

General Comments

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