INT166960

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Context Info
Confidence 0.25
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.65
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TP53) nucleoplasm (TP53) mitochondrion (TP53)
endoplasmic reticulum (TP53) enzyme binding (TP53) protein complex assembly (TP53)
TP53 (Homo sapiens)
Pain Link Frequency Relevance Heat
Cannabinoid receptor 1 88.32 High High
cINOD 5 75.00 Quite High
addiction 2 31.60 Quite Low
antagonist 1 24.04 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 6 99.62 Very High Very High Very High
Colon Cancer 5 96.60 Very High Very High Very High
Cancer 24 92.36 High High
INFLAMMATION 2 70.68 Quite High
Death 2 65.84 Quite High
Breast Cancer 28 50.00 Quite Low
Infection 6 5.00 Very Low Very Low Very Low
Hyperplasia 1 5.00 Very Low Very Low Very Low
Adenocarcinoma 1 5.00 Very Low Very Low Very Low
Immunotherapy Of Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The NAG-1 expression by LYR-8 was not blocked by pifithrin-alpha, a specific p53 inhibitor, which was different from doxorubicin that induced p53-dependent NAG-1 transcriptional activity.
Positive_regulation (induced) of Negative_regulation (inhibitor) of p53
1) Confidence 0.25 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20230799 Disease Relevance 0.89 Pain Relevance 0.26
can induce apoptosis in MEFs, which is enhanced by loss of p53, suggesting a potential role for p53 in regulating apoptosis upon CK1?
Positive_regulation (enhanced) of Negative_regulation (loss) of p53 associated with apoptosis
2) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813871 Disease Relevance 0.76 Pain Relevance 0

General Comments

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