INT166966

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 7.36
Pain Relevance 4.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ccr7) plasma membrane (Ccr7) intracellular (Ccr7)
signal transducer activity (Ccr7)
Anatomy Link Frequency
CD86 3
T cells 3
blood 1
synovium 1
mast cells 1
Ccr7 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 442 100.00 Very High Very High Very High
rheumatoid arthritis 200 99.20 Very High Very High Very High
Central nervous system 236 99.08 Very High Very High Very High
cytokine 221 99.08 Very High Very High Very High
Inflammation 424 92.92 High High
Neuritis 24 90.36 High High
Multiple sclerosis 258 90.04 High High
Spinal cord 78 88.64 High High
Arthritis 33 85.84 High High
Inflammatory response 14 81.76 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 205 99.20 Very High Very High Very High
Central Nervous System Disease 193 99.08 Very High Very High Very High
Multiple Sclerosis 405 97.12 Very High Very High Very High
Bordatella Infection 9 94.92 High High
INFLAMMATION 443 92.92 High High
Epstein-barr Virus 8 92.16 High High
Neurological Disease 48 90.68 High High
Optic Neuritis 24 90.36 High High
Syndrome 20 90.24 High High
Demyelinating Disease 324 90.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CCR7, the common receptor for these two chemokines was expressed on a subpopulation of cells in the perivascular cuffs.
Gene_expression (expressed) of CCR7 associated with chemokine
1) Confidence 0.48 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.63 Pain Relevance 0.47
These cells are known to express CCR7, the receptor for CCL19 and CCL21.
Gene_expression (express) of CCR7
2) Confidence 0.48 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 2.16 Pain Relevance 0.84
Encephalitogenic T cells in vitro showed expression of CCR7 and CXCR3, the alternative receptor for CCL21, and chemotaxed towards both CCL19 and CCL21 in a concentration-dependent and a Pertussis toxin-sensitive manner similar to naïve T cells.
Gene_expression (expression) of CCR7 in T cells associated with bordatella infection
3) Confidence 0.48 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.63 Pain Relevance 0.44
Mouse and human CCRL2/L1.2 cells migrated to CXCL12 and CCL19 (via endogenously expressed CXCR4 and CCR7, respectively), and primary mouse peritoneal mast cells migrated to stem cell factor (SCF), indicating their ability to demonstrate chemotaxis is this assay (Fig. 7, C and D).
Gene_expression (expressed) of CCR7 in mast cells
4) Confidence 0.44 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0.03
TREM2 cross-linking antibodies stimulated phosphorylation of ERK in TREM2-transduced BM-MC (Figure 3), but did not modify cell surface expression of MHC class II, CD80, CD86, CD36, CCR7, and CD11c (Figure S1).
Gene_expression (expression) of CCR7 in CD86
5) Confidence 0.43 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1851623 Disease Relevance 0.61 Pain Relevance 0.22
In the present study we found that 24-hr DINP exposure significantly increased the production of the TH2-attracting chemokines TARC/CCL17 (Figure 3A) and MDC/CCL22 (Figure 3B) but not the TH1-polarizing cytokine IL-12p40 (data not shown), and increased the expression of CCR7, CXCR4 (Figure 3C,D), MHC class II, CD80, and CD86 (Figure 3E,F) in BMDCs.
Gene_expression (expression) of CCR7 in CD86 associated with chemokine and cytokine
6) Confidence 0.41 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0.25 Pain Relevance 0.24
Even CCR7?
Gene_expression (Even) of CCR7
7) Confidence 0.41 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.72 Pain Relevance 0.28
Mature myeloid DC in perivascular, T-cell-enriched areas of synovial tissue are further characterized by expression of CD86, DC-LAMP and CCR7, and are associated with, and presumably attracted by, cells expressing the chemokines CCL19 (SLC) and CCL21 (ELC) [11,16,94].
Gene_expression (expression) of CCR7 in T-cell associated with chemokine
8) Confidence 0.39 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206384 Disease Relevance 0.43 Pain Relevance 0.16
Normal resting CD4+ T cells and primed non-activated T cells expressed mRNA for CCR1, CCR2, CCR3, CCR5, CCR6, CCR7 and CCR8.
Gene_expression (expressed) of CCR7 in T cells
9) Confidence 0.37 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.77 Pain Relevance 0.52
As opposed to the situation in lymph nodes, CCL19 and CCL21, which control the migration of mature DCs, were rarely expressed in RA synovium and their associated receptor CCR7 was poorly expressed [32].
Gene_expression (expressed) of CCR7 in synovium associated with rheumatoid arthritis
10) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582809 Disease Relevance 0.41 Pain Relevance 0.29
Mature myeloid DCs are characterized by the expression of CD86, DC-LAMP and CCR7, which is the receptor for the chemokines CCL19 and CCL21.
Gene_expression (expression) of CCR7 in CD86 associated with chemokine
11) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582809 Disease Relevance 0.67 Pain Relevance 0.54
More extensive phenotyping failed to demonstrate uniform loss of CD62L or CCR7 expression on all TCR?
Gene_expression (expression) of CCR7
12) Confidence 0.30 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0 Pain Relevance 0
METHODS: Peripheral blood T cell subsets were longitudinally evaluated by flow cytometry through the analysis of CD28, CD45RA, and CCR7 expression in 16 patients with RA who were treated with abatacept.
Gene_expression (expression) of CCR7 in blood
13) Confidence 0.15 Published 2010 Journal J. Rheumatol. Section Body Doc Link 20231200 Disease Relevance 0 Pain Relevance 0
In this context PGE2 promotes the function (but not the expression) of the chemokine receptor CCR7, so that DCs efficiently respond to the chemokines CCL19 and CCL21.
Neg (not) Gene_expression (expression) of chemokine receptor CCR7 associated with chemokine
14) Confidence 0.05 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2718617 Disease Relevance 0.08 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox