INT166983

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.66
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-B, HSPG2) extracellular space (HSPG2) small molecule metabolic process (HSPG2)
extracellular region (HSPG2) extracellular matrix organization (HSPG2) lipid metabolic process (HSPG2)
HLA-B (Homo sapiens)
HSPG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
carbamazepine 17 99.84 Very High Very High Very High
antiepileptic Drug 5 99.12 Very High Very High Very High
cINOD 8 98.48 Very High Very High Very High
Lamotrigine 8 96.72 Very High Very High Very High
anticonvulsant 1 93.80 High High
corticosteroid 19 88.96 High High
withdrawal 8 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Staphylococcus Infection 202 100.00 Very High Very High Very High
Bullous Skin Disease 112 100.00 Very High Very High Very High
Syndrome 84 100.00 Very High Very High Very High
Drug Hypersensitivity 17 98.52 Very High Very High Very High
INFLAMMATION 7 98.24 Very High Very High Very High
Genetic Predisposition To Disease 2 88.04 High High
Adverse Drug Reaction 12 87.04 High High
Cicatrix 3 81.56 Quite High
Keratoconjunctivitis 1 78.08 Quite High
Disease 24 77.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We previously reported that carbamazepine (CBZ)-SJS/TEN is strongly associated with the HLA-B*1502 in Han Chinese, which has been confirmed in other Southeast Asian countries where the allele is prevalent.
HLA-B Binding (associated) of SJS associated with staphylococcus infection, syndrome and carbamazepine
1) Confidence 0.08 Published 2010 Journal Pharmacogenomics Section Abstract Doc Link 20235791 Disease Relevance 0.74 Pain Relevance 0.32
A unique and strong association between HLA, drug hypersensitivity and ethnic background was discovered by Chung et al. who showed a strong association in Han Chinese between the HLA-B*1502, SJS and carbamazepine [30].
HLA-B Binding (association) of SJS associated with bullous skin disease, drug hypersensitivity and carbamazepine
2) Confidence 0.04 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.25 Pain Relevance 0.16
HLA B*38 showed only a weak association with sulfamethoxazole induced SJS/TEN54 in contrast to antiepileptic drugs and allopurinol where HLA associations are stronger and ethnically related.112
HLA B Binding (association) of SJS associated with syndrome and antiepileptic drug
3) Confidence 0.02 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846744 Disease Relevance 1.54 Pain Relevance 0.40
We also found that HLA-B*5901 was weakly associated with SJS/TEN with ocular complications although when we corrected the p-value for the number of alleles detected, the result ceased to be significant.
HLA-B Binding (associated) of SJS associated with staphylococcus infection and syndrome
4) Confidence 0.01 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2274925 Disease Relevance 1.13 Pain Relevance 0

General Comments

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