INT166994

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Context Info
Confidence 0.47
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.80
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Agrp)
Agrp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 16 100.00 Very High Very High Very High
Endogenous opioid 2 99.84 Very High Very High Very High
antagonist 4 99.54 Very High Very High Very High
Kappa opioid receptor 1 99.12 Very High Very High Very High
narcan 2 98.56 Very High Very High Very High
Opioid 1 97.76 Very High Very High Very High
Cannabinoid 5 96.48 Very High Very High Very High
agonist 5 93.76 High High
Neurotransmitter 1 87.28 High High
Inflammation 5 86.96 High High
Disease Link Frequency Relevance Heat
Weight Gain 5 95.28 Very High Very High Very High
INFLAMMATION 5 86.96 High High
Weight Loss 3 85.68 High High
Appetite Loss 45 85.16 High High
Chronic Disease 4 75.12 Quite High
Sepsis 1 59.44 Quite High
Cancer 5 57.20 Quite High
Acute Renal Failure 1 54.64 Quite High
Obesity 2 46.04 Quite Low
Targeted Disruption 2 42.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-MSH is increased and the secretion of AGRP is decreased from hypothalamic explants in response to IL1?
Negative_regulation (decreased) of Localization (secretion) of AGRP
1) Confidence 0.47 Published 2010 Journal The Journal of Endocrinology Section Body Doc Link PMC2887273 Disease Relevance 0.80 Pain Relevance 0.28
The inhibitory effect of rimonabant was also prevented by naloxone and a kappa-opioid receptor selective antagonist, suggesting that GABA release from arcuate NPY/AgRP/GABA neurones can be inhibited by endogenous opioid peptides, and that the release of opioid peptides is sensitive to cannabinoids.
Negative_regulation (inhibited) of Localization (release) of AgRP associated with gaba, cannabinoid, antagonist, endogenous opioid, kappa opioid receptor, narcan and opioid
2) Confidence 0.36 Published 2010 Journal J. Neuroendocrinol. Section Abstract Doc Link 20236227 Disease Relevance 0 Pain Relevance 1.54

General Comments

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