INT167029

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Context Info
Confidence 0.30
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.12
Pain Relevance 3.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (P2rx3)
Anatomy Link Frequency
neuronal 2
nucleus 2
P2rx3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropathic pain 40 99.00 Very High Very High Very High
Antinociceptive 2 98.80 Very High Very High Very High
electroacupuncture 7 97.76 Very High Very High Very High
inferior alveolar nerve 1 96.72 Very High Very High Very High
Pain 53 95.36 Very High Very High Very High
Inflammation 15 95.12 Very High Very High Very High
Sciatic nerve 4 95.12 Very High Very High Very High
agonist 17 92.72 High High
antagonist 28 92.68 High High
Analgesic 1 90.52 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 85 99.00 Very High Very High Very High
Nervous System Injury 39 98.84 Very High Very High Very High
Pain 70 95.36 Very High Very High Very High
INFLAMMATION 18 95.12 Very High Very High Very High
Injury 11 95.12 Very High Very High Very High
Urological Neuroanatomy 4 83.12 Quite High
Apoptosis 4 80.60 Quite High
Neurodegenerative Disease 13 75.60 Quite High
Male Infertility 1 53.04 Quite High
Death 7 52.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The discrepancy in the change of P2X3 expression might be due to the type of nerve injury model, since a recent study using activating transcription factor 3, a neuronal injury maker, has shown that there is an increase in the expression of P2X3 in DRG neurons whose axons had been spared following partial nerve injury [33].
Regulation (change) of Gene_expression (expression) of P2X3 in neuronal associated with nervous system injury and injury
1) Confidence 0.30 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096756 Disease Relevance 0.99 Pain Relevance 0.58
No direct binding of phosphoinositides to the P2X3 subunit
Neg (No) Regulation (direct) of Gene_expression (subunit) of P2X3
2) Confidence 0.24 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734547 Disease Relevance 0 Pain Relevance 0
However, this picture is complicated by a recent report showing P2X7 receptor activation down-regulated the expression of P2X3 in DRGs [85].
Regulation (regulated) of Gene_expression (expression) of P2X3
3) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735677 Disease Relevance 0.73 Pain Relevance 0.70
Moreover, expression of P2X3-containing heteromeric receptors and other subunits was developmentally regulated in nucleus ambiguous motoneurons [61].
Regulation (regulated) of Gene_expression (expression) of P2X3 in nucleus
4) Confidence 0.12 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.22 Pain Relevance 0.23
Conversely, the down-regulated P2X3 receptor expression in the lPAG with antisense oligodeoxynucleotide (ODN) for P2X3 gene significantly attenuated the antinociceptive effect of EA treatment.
Regulation (regulated) of Gene_expression (expression) of P2X3 gene associated with electroacupuncture and antinociceptive
5) Confidence 0.09 Published 2010 Journal Brain Res. Section Abstract Doc Link 20302849 Disease Relevance 1.18 Pain Relevance 1.56

General Comments

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