INT167035

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2011
Negated 3
Speculated 1
Reported most in Body
Documents 25
Total Number 27
Disease Relevance 16.78
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 16
spleen 3
plasma cells 1
lymphocytes 1
bone marrow 1
Cd8a (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 3 99.06 Very High Very High Very High
fluoxetine 7 98.34 Very High Very High Very High
cytokine 206 93.80 High High
rheumatoid arthritis 46 92.84 High High
Inflammatory response 32 90.48 High High
Inflammation 149 89.20 High High
tolerance 24 84.60 Quite High
Inflammatory mediators 3 83.80 Quite High
chemokine 14 77.96 Quite High
Serotonin 1 64.12 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 199 99.88 Very High Very High Very High
Targeted Disruption 65 99.82 Very High Very High Very High
Influenza Virus Infection 183 99.68 Very High Very High Very High
Pox Virus Infection 69 99.52 Very High Very High Very High
Apoptosis 56 99.36 Very High Very High Very High
Infection 502 99.06 Very High Very High Very High
Stress 51 98.78 Very High Very High Very High
Colitis 34 98.68 Very High Very High Very High
Spontaneous Abortion 68 97.84 Very High Very High Very High
Fetal Resorption 4 95.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Control CD8+ T cells stimulated with vaccinia-gp120 did not kill influenza virus-infected target cells in vitro and did not mediate clearance of virus in vivo.
Regulation (Control) of CD8 in T cells associated with pox virus infection and influenza virus infection
1) Confidence 0.41 Published 2007 Journal Respir Res Section Body Doc Link PMC1914056 Disease Relevance 1.41 Pain Relevance 0
The present study showed that CD94 was up-regulated on CD8+T cells from the spleens of ACAID mice.
Regulation (regulated) of CD8 in spleens
2) Confidence 0.39 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.09 Pain Relevance 0
CD8+CD94+T cells were characterized by minimal expression of perforin, granzyme B and Foxp3.
Regulation (characterized) of CD8 in T cells
3) Confidence 0.39 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.07 Pain Relevance 0
They found that CD94 mRNA was up-regulated in OT-1 CD8+Tregs, suggesting that CD94 may play a role in immune regulation by Tregs.
Regulation (regulated) of CD8
4) Confidence 0.39 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.13 Pain Relevance 0
Our studies on chronic stress showed a significant increase in the relative proportion of circulating CD4+ and CD8+ cell subsets when the immobilization period was 2 hours per day.
Regulation (circulating) of CD8 associated with stress
5) Confidence 0.34 Published 2001 Journal BMC Immunol Section Body Doc Link PMC37547 Disease Relevance 0.85 Pain Relevance 0
This experimental design allowed us to analyze the dependency of the CD8+ CTL response in the lung and the spleen on the viral context (i.e.
Spec (analyze) Regulation (response) of CD8 in spleen
6) Confidence 0.32 Published 2008 Journal Virol J Section Body Doc Link PMC2561024 Disease Relevance 1.27 Pain Relevance 0
These pathological events strongly indicated that naive CD8+ T cells could be a critical population for the induction of autoimmune colitis under lymphopenic conditions.
Regulation (population) of CD8 in T cells associated with colitis
7) Confidence 0.26 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2373835 Disease Relevance 0.66 Pain Relevance 0.19
Surprisingly, we found that the self-reactivity mediated by the cooperation of memory-like CD8+ and CD4+ T cells was not abrogated by CD40L blockade.
Neg (not) Regulation (abrogated) of CD8 in T cells
8) Confidence 0.24 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2939396 Disease Relevance 0.34 Pain Relevance 0.12
-MSH/MC-1R signaling is involved in the regulation of cytotoxicity in human CD8+ T cells.
Regulation (regulation) of CD8 in T cells
9) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813861 Disease Relevance 0.64 Pain Relevance 0
In this setting, only 3.8 ± 1.0% of CD8+ T cells expressed CD11c and no changes were observed in the CD3+ CD8- population.
Regulation (population) of CD8 in T cells
10) Confidence 0.17 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 1.04 Pain Relevance 0.13
In our model, the percentage of CD11c+ cells within the CD8+ T cell population differed between the organs assessed, being lowest in MLN and spleen, higher in the blood, where a short-lived increase of these cells was noted during the acute phase of infection, and highest in the lung.
Regulation (population) of CD8 in spleen associated with infection
11) Confidence 0.17 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.52 Pain Relevance 0
Recently, it has been proposed that the bone marrow (BM) is a crucial organ for trafficking of mature T cells and contributes greatly to long-term cytotoxic memory as well as to homeostatic regulation of peripheral CD8 T cell numbers [24].
Regulation (regulation) of CD8 in bone marrow
12) Confidence 0.15 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2873659 Disease Relevance 0.21 Pain Relevance 0
Mice treated with LPS in group B, had a higher uterine CD4+ T lymphocyte number, with no significant change in the CD8+ lymphocytes.
Neg (no) Regulation (change) of CD8 in lymphocytes
13) Confidence 0.14 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2958556 Disease Relevance 0 Pain Relevance 0
Infection with highly virulent influenza A strains down-regulated CD8+ T cell responses [33].
Regulation (regulated) of CD8 in T cell associated with influenza virus infection, sprains and strains and infection
14) Confidence 0.12 Published 2007 Journal Virol J Section Body Doc Link PMC1810241 Disease Relevance 2.22 Pain Relevance 0
In conclusion, our study provides evidence that alterations in both the CD4+/CD8+ and IFN-?
Regulation (alterations) of CD8
15) Confidence 0.09 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2958556 Disease Relevance 0.48 Pain Relevance 0.19
However, we clearly cannot dismiss a role for enhanced antiviral CD8+ T cell responses in M2.Stop infected mice in controlling the frequency of virus infected plasma cells.
Regulation (role) of CD8 in plasma cells
16) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.08 Pain Relevance 0
CD8+ T cell levels remained unchanged in the acute phase and showed a significant increase in the chronic phase of Ninoa infection, in agreement with their timing for expansion and contraction phases in T. cruzi infection [40].
Neg (unchanged) Regulation (unchanged) of CD8 in T cell associated with infection
17) Confidence 0.08 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2852613 Disease Relevance 0.78 Pain Relevance 0.10
Interestingly, in Balb/c mice, the primary pulmonary CD8 T cell response against influenza A/Japan/305/57(H2N2) was mainly directed against three epitopes in the HA and one in the NP [35], suggesting that CD8 T cell responses are strongly dependent on the infecting virus strain and the host genetic background.
Regulation (dependent) of CD8 in T cell associated with influenza virus infection and sprains and strains
18) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922371 Disease Relevance 1.10 Pain Relevance 0.04
METHODS: CD4(+) T-cell-negative I-Abeta chain(-/-) (Ab0) mice develop AIP spontaneously, likely due to dysregulation of CD8(+) T- cell responses.
Regulation (dysregulation) of CD8 in T-cell
19) Confidence 0.05 Published 2010 Journal Gastroenterology Section Body Doc Link 20303356 Disease Relevance 0.19 Pain Relevance 0
Furthermore, several studies have demonstrated the virtual disappearance of naïve CD8+ T-cells in the elderly associated with a significant increase in the proportions of differentiated effector memory and effector CD8+ T-cells in comparison to younger individuals.
Regulation (effector) of CD8 in T-cells
20) Confidence 0.05 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2615427 Disease Relevance 0.52 Pain Relevance 0

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