INT167038

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.13
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Aip) protein folding (Aip) cytosol (Aip)
nucleus (Aip) cytoplasm (Aip)
Anatomy Link Frequency
plasma cells 1
leukocyte 1
pancreas 1
Aip (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 75 98.88 Very High Very High Very High
Inflammation 42 96.52 Very High Very High Very High
Bile 12 94.16 High High
Arthritis 2 11.04 Low Low
fibrosis 18 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Crohn's disease 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
backache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 114 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 60 99.80 Very High Very High Very High
Cholangitis 2 98.78 Very High Very High Very High
INFLAMMATION 40 96.52 Very High Very High Very High
Sclerosis 2 96.00 Very High Very High Very High
Hypergammaglobulinemia 4 92.84 High High
Disease 66 91.60 High High
Targeted Disruption 2 75.00 Quite High
Cirrhosis 10 30.36 Quite Low
Biliary Tract Disease 2 24.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An association between AIP and the human leukocyte antigen (HLA)-DRB1*0405/DQB1*0401 haplotype has been reported, but linkage disequilibrium has precluded the identification of predisposing HLA gene(s).
AIP Binding (association) of in leukocyte associated with pancreatitis
1) Confidence 0.21 Published 2010 Journal Gastroenterology Section Abstract Doc Link 20303356 Disease Relevance 0.54 Pain Relevance 0.10
Extra- and/or intrahepatic bile duct lesions histologically characterized by a dense infiltrate of IgG4-positive plasma cells have been reported in up to 74% of AIP-patients, [34] leading to the proposal of an entity called autoimmune IgG4-associated cholangitis [35] and questioning the existence of a previously reported association between AIP and primary sclerosing cholangitis.
AIP Binding (association) of in plasma cells associated with cholangitis, bile, primary sclerosing cholangitis and pancreatitis
2) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 0.85 Pain Relevance 0.05
Autoimmune pancreatitis (AIP) is a recently recognized clinicopathological entity, which was first described by Sarles in 1961 as a “chronic inflammatory sclerosis of the pancreas” of possible autoimmune pathogenesis associated with hypergammaglobulinemia.[1] The disease has been gaining new attention for the last two decades, and the term “autoimmune pancreatitis”, coined by Yoshida in 1995,[2] has only recently been widely accepted in the scientific literature.[3] Due to the possible involvement of the biliary tract, the term autoimmune pancreatocholangitis (AIPC) has been introduced.[4], [5] The main reasons for the rising interest in investigating AIPC reside in its increasing frequency, partly due to an increased awareness of the disease but also due to a potentially increased incidence in the last 20–30 years,[6], [7] its not yet clarified aetiology and pathogenesis and its still undefined clinical spectrum.
AIP Binding (recognized) of in pancreas associated with hypergammaglobulinemia, inflammation, sclerosis, pancreatitis and disease
3) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 0.74 Pain Relevance 0.05

General Comments

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