INT167039

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.40
First Reported 2003
Last Reported 2011
Negated 3
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 17.12
Pain Relevance 2.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Cd74) signal transduction (Cd74) Golgi apparatus (Cd74)
endoplasmic reticulum (Cd74) plasma membrane (Cd74) protein complex assembly (Cd74)
Anatomy Link Frequency
monocytes 3
granulocytes 1
lymphocytes 1
bone marrow 1
skin 1
Cd74 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 398 100.00 Very High Very High Very High
psoriasis 2 99.84 Very High Very High Very High
Inflammatory response 18 98.40 Very High Very High Very High
Arthritis 121 98.36 Very High Very High Very High
Inflammation 257 95.28 Very High Very High Very High
chemokine 71 88.64 High High
cytokine 114 88.32 High High
Pain 11 86.36 High High
metalloproteinase 10 78.48 Quite High
imagery 6 58.40 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 398 100.00 Very High Very High Very High
Targeted Disruption 119 99.88 Very High Very High Very High
Psoriasis 4 99.84 Very High Very High Very High
Immunization 19 99.60 Very High Very High Very High
Fracture Healing 64 99.42 Very High Very High Very High
Hepatitis C Virus Infection 408 99.40 Very High Very High Very High
Chronic Lymphoid Leukemia 1 99.40 Very High Very High Very High
Hyperplasia 7 99.20 Very High Very High Very High
Infection 177 99.16 Very High Very High Very High
Cancer 183 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Because HLA-DR*0405 expression fails to protect mice from AIP, the HLA-DRB1*0405 allele appears to be an important risk factor for AIP on the HLA-DRB1*0405/DQB1*0401 haplotype.
Gene_expression (expression) of HLA-DR
1) Confidence 0.40 Published 2010 Journal Gastroenterology Section Body Doc Link 20303356 Disease Relevance 0.11 Pain Relevance 0
While CD74 mediates MIF binding, a co-receptor, CD44, is required for ERK 1 and 2 phosphorylation.30,31 Blocking of MIF or MIF signalling, by blocking CD74 attenutates prostate cancer invasiveness.32 Conversely, activation of CD44 promotes breast cancer cell invasion.33 CD44+ breast cancer cells with low or undetectable CD24 have been found to be more tumourigenic and have a characteristic ‘invasiveness gene signature’.34 Studies have also shown that CD44-positive prostate cancer and breast cancer cell lines demonstrate rapid adhesion to bone marrow endothelial cells which can be blocked by neutralizing CD44 antibody.35 B lymphocytes that accumulate in chronic lymphocytic leukaemia have been found to have high expression of CD74 and stimulation of these cells with MIF induces anti-apoptotic Bcl-2 and promotes survival through an IL-8-dependent mechanism.36 Blocking MIF signalling in this context decreases using anti-CD74 antibodies decreases cell survival.


Gene_expression (expression) of CD74 in bone marrow associated with chronic lymphoid leukemia, breast cancer, apoptosis, adhesions and reprotox - general 1
2) Confidence 0.36 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.36 Pain Relevance 0
is able to reduce the expression of HLA-DR on myeloid RA cells where this is brought back to normal upon the addition of anti-TNF?.
Gene_expression (expression) of HLA-DR associated with rheumatoid arthritis
3) Confidence 0.34 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 1.02 Pain Relevance 0.43
EGFr, c-Kit, and CD74 staining also showed an increased mean fluorescence intensity, whereas IL-13R?
Gene_expression (staining) of CD74
4) Confidence 0.27 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 0.41 Pain Relevance 0
Several genes that probably play a role in the inflammatory response characteristic of early stages of fracture healing (FCGRT, Basigin, HLA-A, and CD74) were found to be overexpressed in the PF7 and PF10 ESTs (Table 2).
Gene_expression (overexpressed) of CD74 associated with fracture healing and inflammatory response
5) Confidence 0.13 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1578570 Disease Relevance 0.38 Pain Relevance 0.17
Immunophenotyping including the combination of the fractions of HLA-DR expressing T cell subpopulations with the level of CD40 on monocytes produces an informative pattern, differentiating between infections of bacterial and viral origin.
Gene_expression (expressing) of HLA-DR in monocytes associated with infection
6) Confidence 0.11 Published 2010 Journal BMC Infect Dis Section Abstract Doc Link PMC2912311 Disease Relevance 0.85 Pain Relevance 0.04
Immunophenotyping of lymphocytes and monocytes including quantities of the fractions of HLA-DR expressing T cells and the level of CD40 expression on monocytes can differentiate between acute bacterial and viral infections.
Gene_expression (expressing) of HLA-DR in monocytes associated with viral infection
7) Confidence 0.11 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2912311 Disease Relevance 0.95 Pain Relevance 0.09
Furthermore, immunisation of transgenic mice expressing RA-associated HLA-DR4/DR1 haplotypes with type II collagen results in arthritis [1,2] and reveals a single immunodominant epitope (amino acids 261 to 273) that overlaps the immunodominant epitope in DBA/1 mice with collagen-induced arthritis (CIA) (256 to 270) [1,3].
Gene_expression (expressing) of HLA-DR4 associated with targeted disruption, immunization, rheumatoid arthritis and arthritis
8) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212575 Disease Relevance 1.63 Pain Relevance 0.61
Several stimulating peptides within HCV F protein were identified as HLA-DR or HLA-DP presenting epitopes.


Gene_expression (presenting) of HLA-DR associated with hepatitis c virus infection
9) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997803 Disease Relevance 0.86 Pain Relevance 0
While these cells maintain a highly activated phenotype indicated by high expression of CD69, transferrin receptor and HLA-DR, they are nonetheless hyporesponsive to antigenic stimulation [8-10].
Gene_expression (expression) of HLA-DR
10) Confidence 0.09 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453771 Disease Relevance 0.70 Pain Relevance 0.32
This study showed that TAMs expressed with HLA-DR and IL-10 rather than TGF-?
Gene_expression (expressed) of HLA-DR
11) Confidence 0.09 Published 2010 Journal J Transl Med Section Body Doc Link PMC2841127 Disease Relevance 0.96 Pain Relevance 0
In the healthy control with HLA-DR1 or -DP4 genotype, the three peptides did not stimulate obvious IFN-?
Gene_expression (genotype) of HLA-DR1
12) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997803 Disease Relevance 0.16 Pain Relevance 0.04
The transgenic mice expressing the human HLA-DR1 or HLA-DP4 molecules [18] were intramuscularly immunized twice with gWiz-F. 7 days after the second injection, splenocytes from immunized mice were isolated and subjected to in vitro proliferation assays co-cultured with F protein-derived 15-mer peptides individually (Table 1).
Gene_expression (expressing) of HLA-DR1 associated with targeted disruption
13) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997803 Disease Relevance 1.41 Pain Relevance 0
production following the re-stimulation of the cognate peptides (p65 for HLA-DR1, p57 and p69 for HLA-DP4 subjects).
Gene_expression (production) of HLA-DR1
14) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997803 Disease Relevance 0.65 Pain Relevance 0.04
Another group demonstrated that mRNA levels of the CXCL8 receptors CXCR1 and CXCR2 were 10-fold elevated in injured psoriatic epidermis as compared with normal skin, suggesting a role for high expression of CXCL8 receptors in epidermal hyperplasia, leukocyte infiltration, and increased HLA-DR expression in psoriasis [7,32].
Gene_expression (expression) of HLA-DR in skin associated with psoriasis and hyperplasia
15) Confidence 0.07 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.89 Pain Relevance 0.46
CXCL8 was shown to induce the expression of HLA-DR and to be chemotactic and mitogenic for keratinocytes [30,31].
Gene_expression (expression) of HLA-DR in keratinocytes
16) Confidence 0.07 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.56 Pain Relevance 0.32
Third, we measured expression of TLR-2, TLR-4, and HLA-DR because these receptors are integral components of the host response to infection and are involved in activating the inflammatory and coagulant response to infection [52], [53], [54].
Gene_expression (expression) of HLA-DR associated with inflammation and infection
17) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973976 Disease Relevance 0.94 Pain Relevance 0.08
We assessed cell surface marker expression on monocytes and granulocytes for HLA-DR and toll-like receptor (TLR)-2 and TLR-4.
Gene_expression (expression) of HLA-DR in granulocytes
18) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973976 Disease Relevance 0.26 Pain Relevance 0.05
Immunophenotyping of lymphocytes and monocytes including quantities of the fractions of HLA-DR expressing T cells and the level of CD40 expression on monocytes can differentiate between acute bacterial and viral infections.
Gene_expression (expressing) of HLA-DR in lymphocytes associated with viral infection
19) Confidence 0.04 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2912311 Disease Relevance 0.95 Pain Relevance 0.09
Human CD4 molecules were stable expressed from day 21 until the end of the experiment whereas human HLA-DR3 molecules were not expressed until day 40 (Figure 6A+B) indicating that the recurrence of host HLA-DR3 presenting cells was later than host CD4 T cells.
Neg (not) Gene_expression (expressed) of HLA-DR3 in T cells associated with recurrence
20) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701999 Disease Relevance 0.25 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox