INT167049

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 3
Total Number 44
Disease Relevance 3.47
Pain Relevance 6.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ednra) plasma membrane (Ednra) signal transducer activity (Ednra)
Anatomy Link Frequency
granule cells 8
nerve 6
neurons 4
oligodendrocytes 4
brain 2
Ednra (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 2058 99.96 Very High Very High Very High
GABAergic 504 99.52 Very High Very High Very High
antagonist 55 99.48 Very High Very High Very High
tolerance 5 98.92 Very High Very High Very High
Central nervous system 127 98.76 Very High Very High Very High
analgesia 2 98.36 Very High Very High Very High
Morphine 1 97.96 Very High Very High Very High
opioid receptor 3 97.84 Very High Very High Very High
Action potential 252 97.24 Very High Very High Very High
agonist 5 97.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Toxicity 85 99.90 Very High Very High Very High
Nervous System Injury 42 99.04 Very High Very High Very High
Blister 84 96.24 Very High Very High Very High
Neurological Disease 84 93.44 High High
Pressure And Volume Under Development 84 93.16 High High
Death 168 89.00 High High
Increased Venous Pressure Under Development 85 81.76 Quite High
Diarrhoea 42 73.84 Quite High
Renal Disease 42 73.28 Quite High
Premature Birth 40 70.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with the binding of ET on granule cell pericaryon, the electrophysiological measurements performed on granule cells showed that the membrane resistance is lowered by a factor ?
ET Binding (binding) of in granule cell
1) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0.08 Pain Relevance 0.11
By analyzing the staining of ET and cell markers of interest we established that ET binds to the cell body and dendrites of granule neurons and oligodendrocytes, but not to the astroglial cells, GABAergic neurons, or nerve terminals in the cerebellar cortex.
ET Binding (binds) of in cerebellar cortex associated with gabaergic
2) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0.05 Pain Relevance 0.11
On one hand, 125I-labelled ET binds and forms pores in membranes purified from rat brain synaptosomes [11], [14], [26].
ET Binding (binds) of in brain
3) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0.33 Pain Relevance 0.23
The possible presence of ET on a specific cell type (identified on the basis of an immuno-labeling against a marker of interest) was tested: if ET binds to a cell type expressing a specific marker of interest, the respective intensities of the corresponding fluorescent immuno-signals should be positively correlated.
ET Binding (binds) of
4) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0 Pain Relevance 0.08
While the ETA receptor has a much greater affinity for ET-1 as compared to ET-2 and ET-3, the ETB receptor binds all three members with equal affinity [58].
ETA receptor Binding (binds) of
5) Confidence 0.06 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.33 Pain Relevance 0.06
Since ET binds to granule cells in absence of Ca2+ ions (see above, and data not shown), this finding suggests that glutamate release is mediated by a Ca2+-dependent process.
ET Binding (binds) of in granule cells associated with glutamate
6) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0.07 Pain Relevance 0.27
After binding to specific, yet unknown, membrane acceptor(s) ET undergoes a cholesterol-dependent heptamerization leading to the formation of a transmembrane pore [8]–[12].
ET Binding (binding) of in pore
7) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0.39 Pain Relevance 0
Since ET binds to granule cell somata (Table 1, Fig. 2) and has effects on them in primary culture (see above, Fig. 3), we examined whether and how ET acts on the cell body of granule cells.
ET Spec (examined) Binding (binds) of in granule cells
8) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0 Pain Relevance 0.11
This suggests that only specific membrane domains allow ET binding as revealed by immunostaining.
ET Binding (binding) of
9) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0 Pain Relevance 0
Since ET binds to capillary endothelial cells and alters the blood brain barrier [23]–[25], the nerve tissue damages caused by ET have been proposed to indirectly result from vasogenic edema [4].
ET Binding (binds) of in nerve associated with pressure and volume under development
10) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0.52 Pain Relevance 0.32
Since ET oligomerization, but not ET binding, depends on the presence of cholesterol [10]–[12], we examined whether cholesterol sequestration by methyl-?
ET Binding (binding) of
11) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0.23 Pain Relevance 0.05
In the molecular layer and the granular layer ET does bind neither to GABAergic interneurons nor to Purkinje cells.
ET Neg (neither) Binding (bind) of in interneurons associated with gabaergic
12) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0 Pain Relevance 0.45
ET binds to oligodendrocytes but not to astrocytes
ET Neg (not) Binding (binds) of in oligodendrocytes
13) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0.06 Pain Relevance 0.03
Since PBS buffer does not contain Ca2+ ions, this indicates that binding of ET to granule cells does not require Ca2+ ions.
ET Binding (binding) of in granule cells
14) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0.08 Pain Relevance 0.13
For example the extent of ET binding on the baso-lateral and apical membranes of renal cells differs [12], and in the acute cerebellar slices, where granule cells are highly differentiated, ET labels their cell body but not axons and nerve terminals.
ET Binding (binding) of in nerve
15) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0 Pain Relevance 0.03
In renal cells or granule neurons, the data suggest that part of the ET action, but not ET binding, relies on cholesterol or integrity of cholesterol containing microdomains: pretreatment with methyl-?
ET Binding (binding) of in neurons
16) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0 Pain Relevance 0
This is supported by observations that i) when Ca2+ ions are lacking in the extracellular medium, ET binds to neuronal membrane but fails to induce glutamate efflux, and ii) pretreatment with methyl-?
ET Binding (binds) of in neuronal associated with glutamate
17) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0 Pain Relevance 0.39
Here we investigated the interaction of centrally administered endothelin ET(A) receptor antagonist, BMS182874, with DAMGO (micro opioid receptor agonist), SNC80 (delta opioid receptor agonist), U50,488H (kappa opioid receptor agonist), and oxycodone (micro and kappa opioid receptor agonist) towards antinociception, tolerance to antinociception and body temperature.
endothelin ET Binding (interaction) of in body associated with antinociception, oxycodone, antagonist, tolerance, kappa opioid receptor, agonist and opioid receptor
18) Confidence 0.06 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20303944 Disease Relevance 0 Pain Relevance 1.44
This contradicts previous reports that GFP-tagged ET binds to astrocytes [25].
ET Binding (binds) of in astrocytes
19) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0 Pain Relevance 0
However, the possibility that ET binds and attacks the neurons remains an open question.
ET Binding (binds) of in neurons
20) Confidence 0.06 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2948003 Disease Relevance 0.09 Pain Relevance 0.06

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