INT167052

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Context Info
Confidence 0.56
First Reported 2004
Last Reported 2010
Negated 6
Speculated 2
Reported most in Body
Documents 43
Total Number 45
Disease Relevance 25.70
Pain Relevance 7.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
leukocytes 4
synovium 3
B-cells 2
lymph node 1
smooth muscle 1
Cr2 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 3370 100.00 Very High Very High Very High
Inflammation 369 99.26 Very High Very High Very High
cva 21 78.28 Quite High
chemokine 90 76.48 Quite High
abdominal pain 11 76.20 Quite High
shoulder pain 1 62.16 Quite High
Arthritis 150 46.64 Quite Low
imagery 4 41.68 Quite Low
Pain 38 25.00 Low Low
cINOD 30 25.00 Low Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 3370 100.00 Very High Very High Very High
Cancer 90 99.76 Very High Very High Very High
INFLAMMATION 410 99.26 Very High Very High Very High
Epstein-barr Virus 32 99.16 Very High Very High Very High
Chronic Lymphoid Leukemia 24 98.60 Very High Very High Very High
Severe Combined Immunodeficiency 480 98.50 Very High Very High Very High
Sarcoma 41 95.52 Very High Very High Very High
Necrosis 15 94.60 High High
Synovitis 159 93.52 High High
Disease 380 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A final and highly relevant observation obtained in the HuRA-SCID chimera is that the RA synovium, in the presence of follicular structures expressing AID and CD21L, behaves as a self-sustained microanatomical unit of ectopic lymphoid tissue.
Gene_expression (expressing) of CD21L in synovium associated with severe combined immunodeficiency and rheumatoid arthritis
1) Confidence 0.56 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.44 Pain Relevance 0.09
By evaluating the expression of CD21L and AID mRNA using QT-PCR, a sensitive and highly specific method, we were able to identify functional sites of ectopic lymphoneogenesis in about 50% of the RA synovial samples.
Gene_expression (expression) of CD21L associated with rheumatoid arthritis
2) Confidence 0.56 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.42 Pain Relevance 0.08
To evaluate whether the sustained expression of AID and CD21L mRNA in RA synovial grafts was associated with dynamic gene expression regulating ectopic lymphoneogenesis, we analysed mRNA expression levels of CXCL13, LT?
Gene_expression (expression) of CD21L mRNA associated with rheumatoid arthritis
3) Confidence 0.56 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.51 Pain Relevance 0.29
We next examined a) the direct functional relationship between the synovial expression of AID and CD21L and the production of ACPA and b) whether ectopic lymphoid aggregates within RA synovium maintain functionality independently from incoming immune cells from the periphery.
Gene_expression (expression) of CD21L in immune cells associated with rheumatoid arthritis
4) Confidence 0.56 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.79 Pain Relevance 0.31
In this cohort, we investigated the expression of CD21L, a marker exclusively expressed by FDCs [48], and AID transcripts.
Spec (investigated) Gene_expression (expression) of CD21L
5) Confidence 0.56 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.49 Pain Relevance 0.25
Spearman's rank correlation was performed to correlate expression levels of AID and CD21L mRNA in RA synovial grafts.
Gene_expression (expression) of CD21L mRNA associated with rheumatoid arthritis
6) Confidence 0.56 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.22 Pain Relevance 0.08
Finally, even low-level expression of AID and CD21L within the transplants was still associated with significant ACPA detection in the sera, while ACPA were barely detectable in the absence of AID mRNA expression in the RA grafts.
Gene_expression (expression) of CD21L associated with rheumatoid arthritis
7) Confidence 0.56 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.48 Pain Relevance 0.20
(ii) AID and CD21L expression in RA synovial grafts is associated with the up-regulation of genes regulating ectopic lymphoneogenesis.
Gene_expression (expression) of CD21L associated with rheumatoid arthritis
8) Confidence 0.56 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.65 Pain Relevance 0.33
These proteins also modulate the inflammatory process by the complement receptors CR1/CD35, CR2/CD21, CR3/ CD11b-CD18, CR4/CD11c-CD18 and C5aR, expressed on leukocytes [13-17].
Gene_expression (expressed) of CD35 in leukocytes associated with inflammation
9) Confidence 0.51 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.07 Pain Relevance 0.26
These proteins also modulate the inflammatory process by the complement receptors CR1/CD35, CR2/CD21, CR3/ CD11b-CD18, CR4/CD11c-CD18 and C5aR, expressed on leukocytes [13-17].
Gene_expression (expressed) of CR1 in leukocytes associated with inflammation
10) Confidence 0.51 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.08 Pain Relevance 0.26
These proteins also modulate the inflammatory process by the complement receptors CR1/CD35, CR2/CD21, CR3/ CD11b-CD18, CR4/CD11c-CD18 and C5aR, expressed on leukocytes [13-17].
Gene_expression (expressed) of CR2 in leukocytes associated with inflammation
11) Confidence 0.51 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.07 Pain Relevance 0.26
MZ (CD21high CD1dhigh) and FO (CD21int CD1dint) B cells were subsequently sorted based on surface expression of CD21 and CD1d to ?
Gene_expression (expression) of CD21 in B cells
12) Confidence 0.50 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.08 Pain Relevance 0
Overall, these results strongly support the notion that lymphoid structures expressing AID and CD21L can directly contribute to ACPA production within the rheumatoid synovial membrane.
Gene_expression (expressing) of CD21L
13) Confidence 0.48 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.52 Pain Relevance 0.23
m paraffin and/or frozen sections of five RA synovial samples representative of different degrees of histological organization (three aggregate/CD21+, one aggregate/CD21?
Gene_expression (sections) of CD21 associated with rheumatoid arthritis
14) Confidence 0.48 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.37 Pain Relevance 0.19
ACPA+ cells were localised around AID+/CD21+ aggregates (Figure 4D, 4E and 4F), were CD20?
Gene_expression (aggregates) of CD21
15) Confidence 0.48 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.28 Pain Relevance 0.10
Importantly, AID was detected only in the presence of CD21L in synovial grafts and AID mRNA expression levels closely correlated (r=0.88) with those of CD21L (Figure 5G).
Gene_expression (presence) of CD21L
16) Confidence 0.48 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.75 Pain Relevance 0.31
In this cohort, we investigated the expression of CD21L, a marker exclusively expressed by FDCs [48], and AID transcripts.
Spec (investigated) Gene_expression (expression) of CD21L
17) Confidence 0.48 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.49 Pain Relevance 0.25
Based on the results of the CD21 staining and the presence of G2/G3 aggregates, samples were qualitatively classified as either diffuse, aggregate/CD21?
Gene_expression (staining) of CD21
18) Confidence 0.48 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.33 Pain Relevance 0.13
In the same cohort of 25 patients we compared the expression of AID and CD21L mRNA by QT-PCR with histological characterization of the same piece of synovial tissue.
Gene_expression (expression) of CD21L mRNA
19) Confidence 0.48 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.53 Pain Relevance 0.27
The histomorphological analysis described above suggested that ectopic AID+/CD21+ aggregates are capable of sustaining in situ ACPA production in the RA synovium.
Gene_expression (aggregates) of CD21 in synovium associated with rheumatoid arthritis
20) Confidence 0.48 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.68 Pain Relevance 0.26

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