INT167056

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Context Info
Confidence 0.75
First Reported 2006
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 29
Total Number 32
Disease Relevance 20.05
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (CALR) Golgi apparatus (CALR) endoplasmic reticulum (CALR)
intracellular (CALR) DNA binding (CALR) cytoplasm (CALR)
Anatomy Link Frequency
arm 3
lungs 2
blood 1
B-cell 1
kidney 1
CALR (Homo sapiens)
Pain Link Frequency Relevance Heat
Lamotrigine 4 99.46 Very High Very High Very High
agonist 48 92.64 High High
Arthritis 29 90.04 High High
palliative 27 87.68 High High
Pain management 6 84.16 Quite High
Pain 82 82.96 Quite High
Bioavailability 10 75.12 Quite High
corticosteroid 1 74.08 Quite High
GABAergic 16 73.60 Quite High
chemokine 5 72.84 Quite High
Disease Link Frequency Relevance Heat
Recurrence 16 100.00 Very High Very High Very High
Bacteremia 4 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 114 99.74 Very High Very High Very High
Disease 462 99.72 Very High Very High Very High
Onchocerciasis 26 99.42 Very High Very High Very High
Syndrome 26 99.28 Very High Very High Very High
Sjoegrens Syndrome 3 99.06 Very High Very High Very High
Cancer 303 99.04 Very High Very High Very High
Stress 42 98.96 Very High Very High Very High
Pleurisy 2 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tests for anti-extractable nuclear antigens (ENA) (SSA, SSB, SM, SM/RNP, SCL-70 and Jo-1), were also negative.
Neg (negative) Gene_expression (negative) of SSA
1) Confidence 0.75 Published 2007 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC1887527 Disease Relevance 1.18 Pain Relevance 0.19
Reinforcing a medical hypothesis with a new question: is there a subgroup of shrinking lungs syndrome that is induced by pleurisy in systemic lupus erythematosus and is this subgroup marked by anti-Ro/SSA?
Gene_expression (/) of SSA in lungs associated with syndrome, pleurisy and systemic lupus erythematosus
2) Confidence 0.65 Published 2010 Journal Clin. Rheumatol. Section Title Doc Link 20306212 Disease Relevance 0.87 Pain Relevance 0.08
Reinforcing a medical hypothesis with a new question: is there a subgroup of shrinking lungs syndrome that is induced by pleurisy in systemic lupus erythematosus and is this subgroup marked by anti-Ro/SSA?
Gene_expression (marked) of SSA in lungs associated with syndrome, pleurisy and systemic lupus erythematosus
3) Confidence 0.65 Published 2010 Journal Clin. Rheumatol. Section Title Doc Link 20306212 Disease Relevance 0.87 Pain Relevance 0.08
Likewise, in pSS patients receiving B-cell-depleting agents (for example, rituximab or epratuzumab), no changes in anti-SSA and anti-SSB antibodies were detected [26,28].
Gene_expression (antibodies) of SSA in B-cell
4) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246233 Disease Relevance 0.60 Pain Relevance 0.04
The patient with lamotrigine-induced lupus was anti-Ro/SSA positive and had normal anti-DNA, anti-phospholipid antibody and complement levels.
Gene_expression (positive) of SSA associated with lamotrigine and systemic lupus erythematosus
5) Confidence 0.65 Published 2009 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2770548 Disease Relevance 0.75 Pain Relevance 0.17
Anti-double stranded DNA, anti-Sjogrens Syndrome A, anti-Sjogrens Syndrome B and anti-ribonucleoprotein antibodies (anti-SSA, anti-SSB, anti-RNP), anti-Sm, anti-Scl-70, antineutrophil cytoplasmic antibodies, anticardiolipin antibodies, cryoglobulins, C3, C4, C-reactive protein, complete blood count, electrolytes, creatinine, hepatic transaminases, alkaline phosphatase and urinalysis were all normal or negative.
Neg (negative) Gene_expression (negative) of SSA in blood associated with sjoegrens syndrome
6) Confidence 0.58 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2901265 Disease Relevance 0.50 Pain Relevance 0.11
Whether progress can be expected to be comparable in the majority of SSA countries under the existing scenario of prevailing poverty, weak infrastructure and management capacity, unreliable donor funding, underused health services, and high malaria transmission intensity, remains doubtful [17,18].
Gene_expression (countries) of SSA associated with malaria
7) Confidence 0.55 Published 2009 Journal Malar J Section Body Doc Link PMC2790466 Disease Relevance 0.77 Pain Relevance 0
Expression of MT-COMP in the absence of shRNA 3B elevates CRT levels, indicating increased ER stress (Fig. 3F).
Gene_expression (levels) of CRT associated with stress
8) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858657 Disease Relevance 0.57 Pain Relevance 0
Moreover, expression of CRT was also reduced in cells expressing shRNA 3B.
Gene_expression (expression) of CRT
9) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858657 Disease Relevance 0.36 Pain Relevance 0
There appears to be a trend toward higher RRs with gemcitabine-based CRT that must be confirmed in multicenter trials.38,113–115
Gene_expression (based) of CRT
10) Confidence 0.20 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2939765 Disease Relevance 0.72 Pain Relevance 0.17
The estimated 5-year survival rate was 10% among patients assigned to receive CRT and 20% among patients who did not receive CRT (P = 0.05).18 However, this study may have suffered from selection bias and an insufficient sample size for a 2 × 2 study design.19 In addition, there was an excessive rate of local recurrence in the CRT arm, suggesting the radiation schedule was suboptimal.20

Outside the United States, adjuvant chemotherapy remains the focus of trials

Gene_expression (excessive) of CRT in arm associated with recurrence
11) Confidence 0.20 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2939765 Disease Relevance 0.24 Pain Relevance 0
The estimated 5-year survival rate was 10% among patients assigned to receive CRT and 20% among patients who did not receive CRT (P = 0.05).18 However, this study may have suffered from selection bias and an insufficient sample size for a 2 × 2 study design.19 In addition, there was an excessive rate of local recurrence in the CRT arm, suggesting the radiation schedule was suboptimal.20

Outside the United States, adjuvant chemotherapy remains the focus of trials

Gene_expression (receive) of CRT in arm associated with recurrence
12) Confidence 0.20 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2939765 Disease Relevance 0.18 Pain Relevance 0
In the CRT we could not observe
Gene_expression (observe) of CRT
13) Confidence 0.17 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1552030 Disease Relevance 0.30 Pain Relevance 0
On 6 months postoperative radiographs, average SSA was 1.8 ± 3.8 and average SACS 20.9 ± 5.8.
Gene_expression (average) of SSA
14) Confidence 0.13 Published 2010 Journal J Orthop Traumatol Section Body Doc Link PMC2896578 Disease Relevance 0.16 Pain Relevance 0
Preoperatively, average SSA was 0.5 ± 2.1 and average SACS 16.5 ± 4.0.
Gene_expression (average) of SSA
15) Confidence 0.13 Published 2010 Journal J Orthop Traumatol Section Body Doc Link PMC2896578 Disease Relevance 0.15 Pain Relevance 0
No significant overlap of HLA-B27 was observed with the ER-resident chaperone calreticulin (not shown).
Neg (No) Gene_expression (overlap) of calreticulin
16) Confidence 0.12 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575614 Disease Relevance 0 Pain Relevance 0
, calcium-binding proteins such as calmodulin (presumably requiring pharmacological levels because of low affinity), calreticulin, nuclear calreticulin analogs, and two mitochondrial binding sites, one of which is located at the amphipathic ramp of complex 1 and displays high affinity to the indoleamine.19,21,43–45 The majority of synthetic agonists has not been tested for these binding sites, with the exception of ramelteon, which has a low affinity to quinone reductase 2,46 and does not seem to act via calmodulin.21
Gene_expression (analogs) of calreticulin associated with agonist
17) Confidence 0.11 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2699659 Disease Relevance 0.14 Pain Relevance 0.12
In Malawi and elsewhere in SSA, NTS bacteremia typically presents in children less than 3 years of age, especially those with coincident anemia, malaria, malnutrition, and HIV infection [131]–[133].
Gene_expression (presents) of SSA associated with appetite loss, malaria, anaemia, bacteremia, acquired immune deficiency syndrome or hiv infection and infection
18) Confidence 0.10 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2727001 Disease Relevance 2.68 Pain Relevance 0
Lymphatic filariasis (46–51 million cases) and onchocerciasis (37 million cases) are also widespread in SSA, each disease representing a significant cause of disability and reduction in the region's agricultural productivity.
Gene_expression (widespread) of SSA associated with onchocerciasis, lymphatic filariasis and disease
19) Confidence 0.10 Published 2009 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2727001 Disease Relevance 2.32 Pain Relevance 0
Hek293 cells were tested for the expression of each chaperone tested (figure 1b) and Bip, Calnexin, Calreticulin, ERp57, HSP70, PDI and GRP94 were all expressed.
Gene_expression (expression) of Calreticulin
20) Confidence 0.10 Published 2010 Journal J Mol Signal Section Body Doc Link PMC2954983 Disease Relevance 0 Pain Relevance 0

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