INT167064

Context Info Confidence 0.44 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.50 Pain Relevance 0.56

endoplasmic reticulum (Nr3c2) nucleus (Nr3c2) cytoplasm (Nr3c2)

Nr3c2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammation 1 96.20 fibrosis 1 94.52 antidepressant 1 90.60 corticosteroid 8 86.32 Calcium channel 7 84.80 Angina 1 80.48 antagonist 3 75.00 Hippocampus 29 65.04 depression 2 51.32 dexamethasone 1 5.00

Disease Link Frequency Relevance Heat Anxiety Disorder 10 98.04 Vasculitis 1 96.56 Fibrosis 1 94.52 Stress 54 93.32 Hypertension 2 81.84 Cv General 3 Under Development 1 80.48 Post-traumatic Stress Disorder 27 66.64 Apoptosis 2 62.64 Neurodegenerative Disease 2 56.96 Depression 2 51.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Aldosterone-induced activation of mineralocorticoid receptor, a member of the nuclear receptor family, results in increased tissue damage such as vascular inflammation and cardiac and perivascular fibrosis.

Positive_regulation (induced) of Positive_regulation (activation) of mineralocorticoid receptor associated with fibrosis, inflammation and vasculitis

1) Confidence 0.44 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20307534 Disease Relevance 0.35 Pain Relevance 0.35

These studies examined whether changes in hippocampal MR and GR could mediate both behavioral/emotional changes in psychiatric disorders.

Positive_regulation (mediate) of Positive_regulation (hippocampal) of MR

2) Confidence 0.42 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 1.14 Pain Relevance 0.21

General Comments

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